Cytokine profile differentiating Old World and New World hantaviral infections

(Kazan Federal University) Hantavirus infection is acute zoonosis clinically manifesting in two forms: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by Old World hantaviruses, and Hantavirus pulmonary syndrome (HPS), caused by New World hantaviruses. Mild form of HFRS, Nephropaia epidemica (NE), is diagnosed in Tatarstan region of Russia, while HPS is endemic in Americas. Humans become infected by inhaling virus contaminated aerosol of urine and feces.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Conclusions: HFRS in Shandong Province has shown seasonal and spatial clustering characteristics. Middle-aged and elderly farmers are a high-risk population. The BRT model has satisfactory predictive capability in stratifying the regional risk of HFRS at a county level in Shandong Province, which could serve as an important tool for risk assessment of HFRS to deploy prevention and control measures.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Jukka Mustonen Outi Laine Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
In this study, we analyzed the gene sequences of HV isolated from different regions of China in order to trace the molecular evolution of HV and the epidemiological trends of HFRS. A total of 16,6975 HFRS cases and 1,689 HFRS-related deaths were reported from 2004 to 2016, with the average annual incidence rate of 0.9674 per 100,000, 0.0098 per 100,000 mortality rate, and case fatality rate 0.99%. The highest number of cases were detected in 2004 (25,041), and after decreasing to the lowest numbers (8,745) in 2009, showed an incline from 2010. The incidence of HFRS is the highest in spring and winter, and three times as ma...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
by Yidan Li, Bernard Cazelles, Guoqing Yang, Marko Laine, Zheng X. Y. Huang, Jun Cai, Hua Tan, Nils Chr. Stenseth, Huaiyu Tian Seoul hantavirus (SEOV) has recently raised concern by causing geographic range expansion of hemorrhagic fever with renal syndrome (HFRS). SEOV infections in humans are significantly underestimated worldwide and epidemic dynamics of SEOV-related HFRS are poorly understood because of a lack of fiel d data and empirically validated models. Here, we use mathematical models to examine both intrinsic and extrinsic drivers of disease transmission from animal (the Norway rat) to humans in a SEOV-endemic ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Viruses, Vol. 11, Pages 675: Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica Viruses doi: 10.3390/v11070675 Authors: Konstantin Kletenkov Ekaterina Martynova Yuriy Davidyuk Emmanuel Kabwe Anton Shamsutdinov Ekaterina Garanina Venera Shakirova Ilsiyar Khaertynova Vladimir Anokhin Rachael Tarlinton Albert Rizvanov Svetlana Khaiboullina Sergey Morzunov Nephropathia Epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) and linked to hantavirus infection, is endemic in the Republic of Tatarstan. Several genetic markers of HFRS severity have been i...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionsThe clinical course of acute NE was similar in adults and children with high frequency of AKI as well as thrombocytopenia, but with full recovery of all patients.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions/significanceThe southeastern and central Shandong Province are current key HFRS epidemic foci dominated byA.agrarius andR.norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between urbanization and disease dynamics, although it is generally believed that urban living has contributed to reductions in communicable disease burden in industrialized countries. To investigate this relationship, we carried out spatiotemporal analyses using a 48-year-long dataset of hemorrhagi...
Source: Rural Remote Health - Category: Rural Health Authors: Tags: Proc Natl Acad Sci U S A Source Type: research
In this report, we describe anunusual case involving a pregnant woman with HFRS who was in a state of shock. Diagnoses: Hemorrhagic fever with renal syndrome and septic shock. Interventions: Timely termination of pregnancyalong with correction of the shock is very important to curb the inflammation and reduce organ damage. Outcomes: Although HFRS in pregnancy could pose a serious threat to the lives of the mother and the child. Our patient was successfully treated. Lessons: Early and accurate diagnosis, anti-shock treatment, and timely termination of pregnancyare the key aspects of therapy for HFRS with late pregnancy.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In this study, we investigated viral RNA from 76 tissues samples (lung n=30, heart n=6, liver n=18 and kidney n=22) of infected naturall rodent hosts in the area of Central Dinarides caught in live traps. Puumala virus was extracted from 34,7% (16/46) rodents by nested reverse transcriptase polymerase chain reaction (RT-PCR) and real-time RT-PCR. Overall, 18 (21,4%) specimens of internal organs (kidney n=8, liver n=6, heart n=2 and lung n=2) were positive for PUUV. It was shown a high rodent infestation rate in a relatively low number of rodent and their organs, although mice were not caught during the time of high density...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
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