More brain activity is not always better when it comes to memory and attention

(University of Nottingham) Potential new ways of understanding the cause of cognitive impairments, such as problems with memory and attention, in brain disorders including schizophrenia and Alzheimer's are under the spotlight in a new research review.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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aki Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. It has been developed as vaccine carriers for the prevention of lifestyl...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Authors: de Oliveira RW, Oliveira CL, Guimarães FS, Campos AC Abstract Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline. ...
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Conclusions: In this review we will provide animal and human research data on the current clinical neurological uses for CBD individually and in combination with Δ9-THC. We will emphasize the neuroprotective, antiinflammatory, and immunomodulatory benefits of phytocannabinoids and their applications in various clinical syndromes. PMID: 29770251 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease, Published online: 16 May 2018; doi:10.1038/s41386-018-0090-0Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
The human brain is a complex system with a sophisticated structure. As a non-invasive way to measure spontaneous neural activity in the human brain, resting-state functional magnetic resonance imaging has attracted considerable attention (Fox et al., 2007; Wang et al., 2010). Resting-state fMRI using blood oxygenation level dependent (BOLD) signals as neurophysiological indicators can detect spontaneous low-frequency brain activity and has been successfully applied to the diagnosis of neuropsychiatric diseases such as epilepsy (Horstmann et al., 2010; Raj et al., 2010), Alzheimer's disease (AD) (He et al., 2008; Stam, 2010...
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research
(Scripps Research Institute) The new research opens the door to studying common brain conditions such as autism, schizophrenia, addiction and Alzheimer's disease under reproducible conditions in a dish.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Serotonin 6 (5-HT6) receptors are primarily expressed in the central nervous system and to even further extent brain regions responsible for learning and memory. Recent studies have demonstrated 5-HT6 receptor involvement in pathophysiological processes highlighting their therapeutic possibilities. Most research concerning the effects of 5-HT6 receptor modulation has focused on blockade despite paradoxical findings that 5-HT6 agonists and antagonists can both have pro-cognitive effects. The current experiments examine the effects of the 5-HT6 receptor agonist EMD386088 on behavioral flexibility and workin...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Recent studies have suggested that changes in blood lipid profile may be related to the pathogenesis of some important neuropsychiatric diseases such as depression, schizophrenia, and Alzheimer's disease (Demirkan et  al., 2013; Kakefuda et al., 2010; Liu et al., 2015; McEvoy et al., 2013; Sato et al., 2012). Lipids constitute approximately half of the dry weight of the brain and are implicated in important brain functions including membrane composition, signal transduction, and biological messenger functio ns, in addition to physiological processes such as energy metabolism and neuroendocrine func...
Source: Psychiatry Research - Category: Psychiatry Authors: Source Type: research
Abstract Calcium (Ca2+) ions are prominent cell signaling regulators that carry information for a variety of cellular processes and are critical for neuronal survival and function. Furthermore, Ca2+ acts as a prominent second messenger that modulates divergent intracellular cascades in the nerve cells. Therefore, nerve cells have developed intricate Ca2+ signaling pathways to couple the Ca2+ signal to their biochemical machinery. Notably, intracellular Ca2+ homeostasis greatly relies on the rapid redistribution of Ca2+ ions into the diverse subcellular organelles which serve as Ca2+ stores, including the endoplasm...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
During the last decades, the interest devoted to the relationship between the nervous and immune systems has been gradually increasing, up to the point of becoming one of the most fascinating current research topics in medicine. Indeed, a growing bulk of literature has supported the existence of complex and dynamic interactions between the two systems, and how their interplay might be involved in both healthy and pathological conditions (Kerr et al., 2005; Marazziti et al., 2015). Not surprisingly, dysfunctions of the immune system and/or related alterations the hypothalamic-pituitary axis (HPA) have been implicated in the...
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Source Type: research
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