Low-dose CT scanning improves assessment of ankylosing spondylitis patients
(European League Against Rheumatism) The results of a study presented today at the Annual European Congress of Rheumatology 2017 showed that low dose computed tomography is more sensitive than conventional radiographs (X-rays) in the monitoring of disease progression in patients with Ankylosing Spondylitis (AS).
We present a case of a 54-year-old man who had been followed-up for ankylosing spondylitis and presented with pain in the shoulder and pelvic girdles, restricted movement, and morning stiffness for 2 months. Physical examination revealed that the pain was located mostly in the shoulder and pelvic girdles. In addition, increased erythrocyte sedimentation rate revealed the coexistence of the two diseases. Corticosteroid treatment dramatically improved the patient's symptoms and supported the diagnosis. This case demonstrated that ankylosing spondylitis may present polymyalgia-like symptoms, and the two diseases may rarely co...
Publication date: April 2018 Source:Biomedicine & Pharmacotherapy, Volume 100 Author(s): Alireza Rezaiemanesh, Mohsen Abdolmaleki, Kamal Abdolmohammadi, Hamideh Aghaei, Fatemeh Dadgar Pakdel, Yousef Fatahi, Narjes Soleimanifar, Mahdi Zavvar, Mohammad Hossein Nicknam Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune respons...
CONCLUSIONS: CT-P13 was effective and safe in a real-life setting in patients with active RA or AS. PMID: 29439591 [PubMed - as supplied by publisher]
ConclusionThese findings highlight the importance of analyzing patient experiences beyond clinical trial settings and physician reports; continuous assessment of existing PRO instruments in collaboration with patients may increase their utility in real-world settings.FundingNovartis Pharmaceuticals Corporation.
CONCLUSION: ADA provided significant reductions in WBMRI indices of peripheral, axial, and whole-body inflammation in patients with axSpA. WBMRI is promising for objective assessment and monitoring of peripheral and axial disease activity in future clinical trials. PMID: 29449506 [PubMed - as supplied by publisher]
he Swiss Clinical Quality Management Program Abstract OBJECTIVE: To investigate sex differences in connection with the effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with ankylosing spondylitis (AS). METHODS: A total of 440 patients with AS (294 men; 146 women) initiating a first TNFi in the prospective Swiss Clinical Quality Management Cohort were included. We evaluated the proportion of patients achieving the 20% and 40% improvement in the Assessment of Spondyloarthritis international Society criteria (ASAS20 and ASAS40) as well as Ankylosing Spondylitis Disease Activity Score (ASDAS) ...
CONCLUSION: DWI is informative for diagnosis of AS and nr-axSpA, and has moderate utility in assessment of disease activity or treatment response, with performance similar to that of the SPARCC MRI score. PMID: 29449501 [PubMed - as supplied by publisher]
Authors: Benucci M, Damiani A, Bandinelli F, Grossi V, Infantino M, Manfredi M, Gobbi FL, Sarzi-Puttini P, Atzeni F PMID: 29431309 [PubMed - in process]
ConclusionThe incidence of INAAs in SSDs was 42.6%. 65.1% of them present intact neurologic status. The most common neural anomaly was syrinx. Preoperative whole spine MRI must be beneficial for SSDs even in the absence of neurological findings.Graphical abstractThese slides can be retrieved under Electronic Supplementary Material.
INDIANAPOLIS, Feb. 13, 2018 -- (Healthcare Sales &Marketing Network) -- Eli Lilly and Company (NYSE: LLY) announced today that Taltz® (ixekizumab) met the primary and all key secondary endpoints in COAST-V, a Phase 3 study evaluating the safety and e... Biopharmaceuticals Eli Lilly, Taltz, ixekizumab, Ankylosing Spondylitis