Low-dose CT scanning improves assessment of ankylosing spondylitis patients
(European League Against Rheumatism) The results of a study presented today at the Annual European Congress of Rheumatology 2017 showed that low dose computed tomography is more sensitive than conventional radiographs (X-rays) in the monitoring of disease progression in patients with Ankylosing Spondylitis (AS).
Condition: Ankylosing Spondylitis Interventions: Drug: 150 mg open-label secukinumab; Drug: 150 mg double-blinded secukinumab; Drug: 300 mg double-blinded secukinumab Sponsor: Novartis Pharmaceuticals Not yet recruiting
Conclusion: Sleep disturbances are more of a problem in patients with AS compared to healthy patients and in active AS patients compared to inactive ones. However, sleeping postures do not seem to affect either sleep disturbances or disease activity in patients with AS. PMID: 29156863 [PubMed]
Authors: Oskay D, Tuna Z, Düzgün İ, Elbasan B, Yakut Y, Tufan A Abstract Background/aim: Our aim was to investigate the association of kinesiophobia with pain, quality of life, clinical measures, and depression in patients with ankylosing spondylitis (AS). Materials and methods: Patients with AS (n: 163) were enrolled in the study. Kinesiophobia was evaluated with the Tampa Scale of Kinesiophobia (TSK), pain with a visual analog scale (VAS), mobility with Bath Ankylosing Spondylitis Metrology Index (BASMI), disease activity with the Bath AS Disease Activity Index (BASDAI), functional status with the Bath...
CONCLUSIONS Our results suggest that miR-31 is overexpressed in PBMCs of AS patients. Furthermore, miR-31, miR-155, miR-16 and miR-181a may be associated with AS disease activity. PMID: 29150993 [PubMed - in process]
To quantitatively assess fat infiltration in the sacroiliac joints (SIJs) of patients with ankylosing spondylitis (AS) by measuring the fat/water signal ratios of periarticular bone marrow with iterative decomposition of water and fat with echo asymmetry and least square estimation (IDEAL).
CONCLUSION: A high proportion of patients with AS switched, discontinued or modified their TNFi therapy. PMID: 29148281 [PubMed - as supplied by publisher]
Authors: Xu Y, Zhong Y, Zhao M, Tu L, Fan M, Zhang P, Wei Q, Cao S, Li Q, Liao Z, Lin Z, Pan Y, Jin O, Gu J Abstract OBJECTIVES: To evaluate the clinical efficacy and safety in patients with refractory ankylosing spondylitis (AS) initiating 99Tc-MDP therapy and explore the mechanisms. METHODS: Refractory AS patients were enrolled in the clinical trial and received 99Tc-MDP treatments for 3 or 5 courses according to ASAS improvement. Efficacy and safety evaluations were conducted during the follow-up. 37 cytokines were quantified by Luminex at baseline and week 30. p-values
CONCLUSIONS: In this real-life study, GLM showed a high 3-year SOD in patients with inflammatory arthritides with a low rate of discontinuation due to AEs. PMID: 29148406 [PubMed - as supplied by publisher]
CONCLUSIONS: There is an unmet need for future studies to use consistent methodology, capture all relevant information (including HLA-B27 positivity), and investigate under-reported populations (e.g. nr-axSpA; southern hemisphere countries) to estimate the population burden of axSpA. Future studies should aim to address data gaps to provide accurate incidence/prevalence estimates for the global axSpA population. PMID: 29148402 [PubMed - as supplied by publisher]
Authors: Walsh JA, Pei S, Burningham Z, Penmetsa G, Cannon GW, Clegg DO, Sauer BC Abstract OBJECTIVE: To evaluate the effect of access to and distance from rheumatology care on the use of disease-modifying antirheumatic drugs (DMARD) in US veterans with inflammatory arthritis (IA). METHODS: Provider encounters and DMARD dispensations for IA (rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis) were evaluated in national Veterans Affairs (VA) datasets between January 1, 2015, and December 31, 2015. RESULTS: Among 12,589 veterans with IA, 23.5% saw a rheumatology provider. In the general IA ...