Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal

The monitoring of Plasmodium falciparum sensitivity to anti-malarial drugs is a necessity for effective case management of malaria. This species is characterized by a strong resistance to anti-malarial drugs. In ...
Source: Malaria Journal - Category: Infectious Diseases Authors: Source Type: research

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ConclusionAccording to our results, Nested PCR method had higher sensitivity than LM and is suggested as a good approach for malaria detection. Consideration the wide diversity of tested isolates and the importance of vaccine development, which is affected by this diversity, further studies are needed in this regard.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Scientists who resurrected a 50,000-year-old gene sequence have analyzed it to figure out how the world's deadliest malaria parasite jumped from gorillas to humans - giving insight into the origins of one of human history's biggest killers.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Environmental destruction risks increasing the spread of deadly diseases including Ebola and malaria, with serious consequences for future public health
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Date: Wednesday, 11 13, 2019; Speaker: Lawrence Wang, Doctoral Candidate, Immunology Laboratory, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, VRC; Building: Building 45 (Natcher Building); Ruth Kirschstein Auditorium
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 11 13, 2019; Speaker: Laura Amo, Ph.D. , Postdoctoral Fellow, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases; Building: Building 45 (Natcher Building); Ruth Kirschstein Auditorium
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 11 13, 2019; Speaker: Peter Agre, M.D., Nobel Laureate, Distinguished Professor, Johns Hopkins Bloomberg School of Public Health; Building: Building 45 (Natcher Building); Ruth Kirschstein Auditorium
Source: NIH Calendar of Events - Category: American Health Source Type: events
Malaria eradication is a “bold but attainable goal” that could be achieved by 2050, according to a report from 41 of the world’s leading malaria researchers.
Source: JAMA - Category: General Medicine Source Type: research
We reported three cases of possible parasite resistance to artemether-lumefantrine therapy. All subjects had complete parasite clearance when treated with other antimalarial drugs. This observation necessitates the urgent need to re-evaluate artemether-lumefantrine medication in Nigeria since it is one of the most commonly used ACT drug.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Malaria is still a significant public health burden in the tropics. Infection with malaria causing parasites results in a wide range of clinical disease presentations, from severe to uncomplicated or mild, and in the poorly understood asymptomatic infections. The complexity of asymptomatic infections is due to the intricate interplay between factors derived from the human host, parasite, and environment. Asymptomatic infections often go undetected and provide a silent natural reservoir that sustains malaria transmission. This creates a major obstacle for malaria control and elimination efforts. Numerous studies have tried ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Malaria parasites undergo several stages in their complex lifecycle. To achieve reductions in both the individual disease burden and malaria transmission within communities, a multi-stage malaria vaccine with high effectiveness and durability is a more efficacious strategy compared with a single-stage vaccine. Here, we generated viral-vectored vaccines based on human adenovirus type 5 (AdHu5) and adeno-associated virus serotype 1 (AAV1) expressing a fusion protein of the pre-erythrocytic stage Plasmodium falciparum circumsporozoite protein (PfCSP) and the transmission-blocking sexual stage P25 protein (Pfs25). A two-dose h...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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