Outcome and Clinical Significance of Immunophenotypic Markers Expressed in Different Treatment Protocols of Pediatric Patients With T-ALL in Developing Countries

This study aimed to evaluate pediatric patients had T-cell acute lymphoblastic leukemia (T-ALL) at two different Arabic cancer centers regarding their clinic-pathologic, immunophenotypic and cytogenetic features and outcome. Study included 103 patients with median age of 8.9 years. Male to female ratio was 2.6:1. Patients divided into (group I) treated with BFM-90 treatment protocol between February 2003 and June 2007 and (group II) includes all patients treated thereafter by the total therapy study XIII protocol for high-risk ALL. Outcome of patients with T-ALL significantly improved in patients received treatment protocol of ALL with high-risk criteria. This protocol eliminates the bad outcomes effect of several clinical and immunophenotypic markers.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research