Anti-inflammatory, antimicrobial and acetylcholinesterase inhibitory activities of friedelanes from Maytenus robusta branches and isolation of further triterpenoids

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Grasiely F. de Sousa, Mariana G. de Aguilar, Danielle F. Dias, Jacqueline A. Takahashi, Maria Eliza C. Moreira, Sidney A. Vieira Filho, Grácia D.F. Silva, Salomão B.V. Rodrigues, Maria Cristina T. Braga Messias, Lucienir P. Duarte The new pentacyclic triterpenoids friedel-1-en-3,16-dione (1), 1α,29-dihydroxyfriedelan-3-one (2) and 16β,28,29-trihydroxyfriedelan-3-one (3) were isolated from Maytenus robusta branches in addition to the known, but new for this species, triterpenoid 12α,29-dihydroxyfriedelan-3-one (4). The structures and stereochemistry of the novel triterpenoids were established by IR, 1D/2D NMR and HR-APCIMS spectral data. In addition, the biological activity of compound 2 and the previously isolated friedelanes 5–8 (friedelan-3,16-dione, 29-hydroxyfriedelan-3-one, 29-hydroxyfriedelan-3,16-dione and 16β,29-dihydroxyfriedelan-3-one) was investigated. Compounds 2 and 8 were tested for their acetylcholinesterase properties and antimicrobial activity against the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, Listeria monocytogenes, Citrobacter freundii, and the fungus Candida albicans. Compound 2 was the most active compound for both assays, with values of 32.3% acetylcholinesterase inhibition, 42% activity against the fungus Candida albicans and 34% against the bacterium Pseudomonas aeruginosa. Compounds 5–8 were assayed for...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

Related Links:

This study reveals the presence of a multigene defensin family in I. holocyclus with wide antimicrobial activity.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
a J, Jarošová M Abstract Potato proteins are well known for their nutritional, emulsifying, foaming, gel forming or antioxidant properties that all make from them valuable protein source for food industry. Antifungal, antimicrobial and also antiviral properties, described for potato proteins in the review, enrich the possibilities of potato protein usage. Potato proteins were divided into patatin, protease inhibitors and fraction of other proteins that also included, besides others, proteins involved in potato defence physiology. All these proteins groups provide proteins and peptides with antifungal...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Gulcin Tezcan1, Ekaterina V. Martynova1, Zarema E. Gilazieva1, Alan McIntyre2, Albert A. Rizvanov1 and Svetlana F. Khaiboullina1,3* 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Centre for Cancer Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom 3Department of Microbiology and Immunology, University of Nevada, Reno, Reno, NV, United States Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, potential biological applications of PF-SeNPs were explored by antibacterial, antifungal, antioxidant and biocompatibility assays. Materials and Methods Chemicals and Reagents Sodium selenite (98%), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT), Tween 80, methanol, acetate buffer, tetracycline, nystatin, rhodamine 123, caspase-3 kit, Dulbecco’s modified Eagle media (DMEM), Folin-Ciocalteu reagent, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), Dulbecco’s phosphate buffered saline pH 7.4 (DPBS) and fetal bovine serum (FBS) w...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Starter cultures are an important tool that contributes to ensure the safety of fermented meat products. Indeed, the microorganisms that constitute starter cultures may inhibit or reduce the growth of spoilage and/or pathogenic populations through mechanisms, such as production of certain metabolites or competitive exclusion. Thus, the use of starter cultures may reduce the need for chemical additives, such as nitrites and nitrates. Furthermore, the lower residual levels of nitrates and nitrites detected in fermented meat products inoculated with starter cultures are due to the ability of starters to metabolize...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 17 April 2019Source: Microbial PathogenesisAuthor(s): Fatima Nehal, Mouna Sahnoun, Slim Smaoui, Bassem Jaouadi, Samir Bejar, Sbaihia MohammedAbstractA new exopolysaccharide (EPS) was produced by the Lactococcus lactis F-mou strain (LT898177.1) isolated from the Sahrawi camel milk in the Bir-Naam region, Algeria. The most influential production parameters were screened by the Plackett-Burman design for enhancing EPS yield utilizing the Mech-Degla juice as a low-cost raw material. An optimum condition of a 0.49 of inoculum size, a 100 rpm of agitation rate, and a 12 h of incubation peri...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In conclusion, we developed a MCDA-LFB assay for rapid and effective detection of C. albicans. The LOD of the new assay for C. albicans detection from pure cultures was as low as 200 fg. In comparison to other molecular methods (PCR, LAMP) for detection of C. albicans, the MCDA-LFB method is more sensitive, time-saving, and does not require expensive equipment or diagnostic technology. When using the MCDA-LFB assay to detect infected clinical samples, the results were consistent with those of the gold-standard method. This suggests the possibility for further clinical application of our C. albicans-MCDA-LFB assay. Ethics ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Abstract We used a green sol-gel synthesis method to fabricate a novel nanoporous copper aluminosilicate (CAS) material. Nanoporous CAS was characterized using X-ray powder diffraction (XRD), field emission transmission and scanning electron microscopies (FE-TEM/FE-SEM), Fourier transform infrared (FTIR) spectroscopy, and optical analyses. The CAS was also evaluated for use as a promising disinfectant for the inactivation of waterborne pathogens. The antimicrobial action and minimum inhibitory concentration (MIC) of this CAS disinfectant were determined against eight microorganisms (Escherichia coli, Salmonella en...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Publication date: March 2019Source: LWT, Volume 101Author(s): Feng He, Ke Li, Xiaohong Zhang, Ying Yang, Yuanping Fang, Fu XiangAbstractFood spoilage is a global issue, and millions of people suffer from food-borne infections. So it is urgent to search for novel, effective and safe antimicrobial agents. A novel essential oil was obtained from Eremothecium ashbyii H4565, which was identified and conserved in the China Center for Type Culture Collection. The chemical components of the essential oil were analyzed by gas chromatography-mass spectrometry. The results showed that 22 components were identified, and the major comp...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 8 November 2018Source: Food ControlAuthor(s): Song Zhang, Jian Xiong, Wenyong Lou, Zhengxiang Ning, Denghui Zhang, Jiguo YangAbstractsTriglycerol monolaurate (TGML) was widely used as an emulsifier in food, cosmetic and other products, and was generally accepted as safe. In the study, the inhibitory activity of TGML against common foodborne pathogens, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Listeria monocytogenes, Candida albicans and Cryptococcus neoformans was investigated with comparison to sodium benzoate and potassium sorbate. The minimum inhibitory concentra...
Source: Food Control - Category: Food Science Source Type: research
More News: Candida | Indomethacin | Listeria | Staphylococcus Aureus