New aromatic compounds from the rhizomes of Homalomena occulta

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Jing Ye, Peng Yin, Mei-Tian Xiao Three new aromatic compounds, identified as 1-(3′,4′-methylenedioxy-phenyl)-10-(3″-hydroxyphenyl)-decane (1), 1-(3′,4′-methylenedioxy-phenyl)-12-(3″-hydroxyphenyl)-dodecane (2), and 1-(3′,4′-methylenedioxy-phenyl)-12-(3″-hydroxyphenyl)-6Z-dodecylene (3), along with six known compounds (4–9) were isolated from the 95% EtOH extract of Homalomena occulta. Their structures were elucidated by chemical and spectral methods Compounds 4–9 were isolated for the first time from this plant. Compounds 1–3 exhibited inhibitory activity against BACE1, with IC50 values of 0.82–1.09μmol/L. Graphical abstract

Source: Phytochemistry Letters - June 14, 2017 Category: Chemistry Source Type: research