Long-Acting Antipsychotics Tied to Superior Outcomes Long-Acting Antipsychotics Tied to Superior Outcomes
Clozapine and long-acting injectable antipsychotics have the lowest risk for relapse and treatment failure in patients with schizophrenia, a large,'real-world'study shows.Medscape Medical News
If it disagrees with experiment it is wrong. In that simple statement is the key to science. It does not make any difference how beautiful your guess is. It does not make any difference how smart you are, who made the guess, or what his name is – if it disagrees with experiment it is wrong. That is all there is to it.—Richard Feynman (1)
In this issue of Biological Psychiatry, Hartz et al. (1) report evidence for common genetic origins of schizophrenia and addiction using a relatively new method, the polygenic risk score (PRS). Genome-wide association (GWA) has implicated many single nucleotide polymorphisms (SNPs) and genes in psychiatric disease, but identified few functional loci, with notable exceptions, such as the CHRNA5 Asn398Asp locus in smoking, nearly simultaneously implicated by pathway analysis (2). Discovery of circuits, cells, and molecules integral to psychiatric diseases has been accomplished largely without the aid of GWA.
Previous research on moral judgement in healthy adults suggests a complex interplay of automatic, emotional and deliberative processing. We aimed to advance understanding of these processes by examining moral judgement in individuals with schizophrenia, a ...
This article aims to examine the effect of writing when used as self-medication in psychosis and particularly in schizophrenia. It is based on the work of Antonin Artaud, who engaged in writing to reduce his physical and psychological dissociation and intr...
Compared with those admitted for other medical conditions, patients admitted for epilepsy show increases in subsequent schizophrenia readmissions, a new study suggests.Medscape Medical News
The excitatory, ligand-gated α7 nicotinic acetylcholine receptor (nAChR) has been implicated in the pathophysiology of schizophrenia based on convergent genetic, post-mortem, and psychopharmacological studies (reviewed in Freedman, 2014). Preclinical animal studies (reviewed in Lewis et al., 2017), as well as early phase clini cal studies of patients with schizophrenia (Olincy et al., 2006), suggest α7 nAChR agonists may be useful for treatment of cognitive dysfunction in schizophrenia. However, results of larger randomized placebo-controlled clinical trials of α7 nAChR agonists with a primary cognitive o...
We read with great interest the systematic review by Attademo et al. (2017) on the link between environmental pollution and psychotic disorders. We are concerned that the authors failed to include search terms specific to the most extensively studied airborne neurotoxin, lead, thereby missing many important sources relevant to the link between air pollution and schizophrenia.
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Hello Professor Walsh, My name is ------ and I am an undergraduate student at Boston University studying Behavior and Health. I am in my junior year and am looking to gain research experience this summer studying my foremost interest in psychology. that being the prodromal phase of schizophrenia. I am fascinated by psychosis and would like to investigate both the chemical changes in the brain that occur prior to the first episode, and the observable changes in personality. My goal is to... Can someone look over this email I'm sending to a professor I would like to do research with?