Aflibercept May Be Effective for Resistant Exudative AMD Aflibercept May Be Effective for Resistant Exudative AMD

Aflibercept appears to improve outcomes in patients with exudative age-related macular degeneration (AMD) resistant to treatment with ranibizumab or bevacizumab, researchers from Norway report.Reuters Health Information
Source: Medscape Ophthalmology Headlines - Category: Opthalmology Tags: Ophthalmology News Source Type: news

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Clin Ther. 2021 Sep 18:S0149-2918(21)00310-6. doi: 10.1016/j.clinthera.2021.08.011. Online ahead of print.ABSTRACTPURPOSE: Age-related macular degeneration (AMD) is a leading cause of blindness, particularly in higher-income countries. Although dry AMD accounts for 85% to 90% of AMD cases, a comprehensive understanding of the global dry AMD burden is needed.METHODS: A targeted literature review was conducted in PubMed, MEDLINE, Embase, and the Cochrane Database of Systematic Reviews (1995-2019) to identify data on the epidemiology, management, and humanistic and economic burden of dry AMD in adults. A landscape analysis of...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Source Type: research
Contributors : Michael Landowski ; Vijesh J. Bhute ; Tetsuya TakimotoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging is a significant factor in the development of age-related diseases but the molecular underpinnings of how aging disrupts cellular homeostasis to cause retinal disease is unknown. Here, we further our studies on Transmembrane protein 135 (Tmem135), a gene involved in retinal aging, by examining the transcriptomic profiles of wildtype, heterozygous and homozygous Tmem135 mutant posterior eyecup samples through RNA sequencing (RNA-Seq). We found significant gene expr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Aging (Albany NY). 2021 Sep 20;13(undefined). doi: 10.18632/aging.203558. Online ahead of print.ABSTRACTN-retinylidene-N-retinylethanolamine (A2E) plays a central role in age-related macular degeneration (AMD) by inducing angiogenesis and inflammation. A2E effects are mediated at least partly via the retinoic acid receptor (RAR)-α. Here we show that A2E binds and transactivates also peroxisome proliferator-activated receptors (PPAR) and retinoid X receptors (RXR). 9'-cis-norbixin, a di-apocarotenoid is also a ligand of these nuclear receptors (NR). Norbixin inhibits PPAR and RXR transactivation induced by A2E. Moreov...
Source: Aging - Category: Biomedical Science Authors: Source Type: research
Conclusion: The prediction the number of new cases of AMD is not equal across the globe. Our findings indicate the need for more rigorous control and prevention measures in AMD focus on its risk factors for early intervention. The epidemiological estimates reported in this study could inform to identify effective strategies for preventing AMD worldwide.Gerontology
Source: Gerontology - Category: Geriatrics Source Type: research
CONCLUSION: OCT-A is a non-invasive, safe, and reproducible retinal imaging technique with a high sensitivity of detection of MNV in AMD. It provides useful qualitative and quantitative data. The involvement of OCT-A in the treatment decision for MNV in AMD is linked to identifying the "pattern" of the lesion reflecting its active or inactive status.PMID:34540215 | PMC:PMC8435926 | DOI:10.1016/j.amsu.2021.102826
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
Mol Cell Biochem. 2021 Sep 17. doi: 10.1007/s11010-021-04258-3. Online ahead of print.ABSTRACTAging, chronic oxidative stress, and inflammation are major pathogenic factors in the development and progression of age-related macular degeneration (AMD) with the loss of retinal pigment epithelium (RPE). The human RPE contains a subpopulation of progenitors (i.e., RPE stem cells-RPESCs) whose role in the RPE homeostasis is under investigation. We evaluated the paracrine effects of mature RPE cells exposed to oxidative stress (H2O2) on RPESCs behavior through co-cultural, morphofunctional, and bioinformatic approaches. RPESCs sh...
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research
Int J Biol Macromol. 2021 Sep 15:S0141-8130(21)01991-7. doi: 10.1016/j.ijbiomac.2021.09.069. Online ahead of print.ABSTRACTThe usefulness of sirolimus (SIR) in the treatment of diseases that involve retinal degeneration like age-related macular degeneration (AMD) has been well documented. However, the problem still remains probably owing to the peculiar environment of the eye and/or unfavourable physiochemical profile of SIR. In the present work, we aimed to fabricate sirolimus loaded PLGA nanoparticles (SIR-PLGA-NP) and chitosan decorated PLGA nanoparticles (SIR-CH-PLGA-NP) to be administered via non-invasive subconjuncti...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
Mol Cell Biochem. 2021 Sep 17. doi: 10.1007/s11010-021-04258-3. Online ahead of print.ABSTRACTAging, chronic oxidative stress, and inflammation are major pathogenic factors in the development and progression of age-related macular degeneration (AMD) with the loss of retinal pigment epithelium (RPE). The human RPE contains a subpopulation of progenitors (i.e., RPE stem cells-RPESCs) whose role in the RPE homeostasis is under investigation. We evaluated the paracrine effects of mature RPE cells exposed to oxidative stress (H2O2) on RPESCs behavior through co-cultural, morphofunctional, and bioinformatic approaches. RPESCs sh...
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research
CONCLUSION: Diabetes, beyond diabetic retinopathy, increases the risk of numerous eye disorders leading to low vision with implications for daily diabetes management. Even in the absence of clearly demonstrated benefit from glucose control in all eye conditions, achieving good glycaemic control and adherence to diabetes treatment will likely help avoid an additional risk of visual impairment in people with diabetes. In perspective, interesting findings suggesting a preventive effect of metformin use on age-related macular degeneration occurrence justify further studies.PMID:34534696 | DOI:10.1016/j.diabet.2021.101279
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Source Type: research
Br J Ophthalmol. 2021 Sep 13:bjophthalmol-2021-319383. doi: 10.1136/bjophthalmol-2021-319383. Online ahead of print.ABSTRACTOBJECTIVE: Predicting the impact of neovascular age-related macular degeneration (nAMD) service disruption on visual outcomes following national lockdown in the UK to contain SARS-CoV-2.METHODS AND ANALYSIS: This retrospective cohort study includes deidentified data from 2229 UK patients from the INSIGHT Health Data Research digital hub. We forecasted the number of treatment-naïve nAMD patients requiring anti-vascular endothelial growth factor (anti-VEGF) initiation during UK lockdown (16 March 2...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
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