Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy
Orexin is a neuropeptide that plays a key role in maintaining a state of arousal, and possibly associates with sleep apnea syndrome (SAS). Reduced orexin immunoreactivity has been reported in various neurologic conditions such as narcolepsy, Alzheimer ’s disease, Lewy body disease and multiple system atrophy (MSA); however, there has been no report investigating orexin in Perry syndrome, a rare hereditary neurodegenerative disease characterized by four clinical cardinal signs (parkinsonism, depression/apathy, weight loss, and central hypoventil ation).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Takayasu Mishima, Koji Kasanuki, Shunsuke Koga, Monica Castanedes-Casey, Zbigniew K. Wszolek, Yoshio Tsuboi, Dennis W. Dickson Tags: Short communication Source Type: research
More News: Alzheimer's | Brain | Depression | Narcolepsy | Neurology | Sleep Apnea | Sleep Disorders | Sleep Medicine | Weight Loss