Measurement of the Maximum Frequency of Electroglottographic Fluctuations in the Expiration Phase of Volitional Cough as a Functional Test for Cough Efficiency
AbstractThe hypotheses of the present study were that the maximum frequency of fluctuation of electroglottographic (EGG) signals in the expiration phase of volitional cough (VC) reflects the cough efficiency and that this EGG parameter is affected by impaired laryngeal closure, expiratory effort strength, and gender. For 20 normal healthy adults and 20 patients diagnosed with unilateral vocal fold paralysis (UVFP), each participant was fitted with EGG electrodes on the neck, had a transnasal laryngo-fiberscope inserted, and was asked to perform weak/strong VC tasks while EGG signals and a high-speed digital image of the larynx were recorded. The maximum frequency was calculated in the EGG fluctuation region coinciding with vigorous vocal fold vibration in the laryngeal HSDIs. In addition, each participant underwent spirometry for measurement of three aerodynamic parameters, including peak expiratory air flow (PEAF), during weak/strong VC tasks. Significant differences were found for both maximum EGG frequency and PEAF between the healthy and UVFP groups and between the weak and strong VC tasks. Among the three cough aerodynamic parameters, PEAF showed the highest positive correlation with the maximum EGG frequency. The correlation coefficients between the maximum EGG frequency and PEAF recorded simultaneously were 0.574 for the whole group, and 0.782/0.717/0.823/0.688 for the male/female/male-healthy/male-UVFP subgroups, respectively. Consequently, the maximum EGG frequency m...
Conclusions Small-airway dysfunction is present in patients with chronic cough and BHR. FEF25%-75% has value as a negative predictive parameter for BHR, especially when combined with FENO. FENO > 43 ppb and FEF25%-75% < 78.5% strongly predicted a positive bronchial provocation test.
Conclusions: Treatment with Erdosteine plus standard therapy in AECOPD is effective by improving both clinical symptoms, and large airway impairment with a more rapid and complete recovery of exacerbation compared with placebo. Mucoactive agents with relevant antioxidant activity may allow a more rapid and complete recovery of exacerbated patients by reducing airway inflammation.
Conclusion: Obesity is associated with lower lung function and increased burden of obstructive pulmonary symptoms despite preserved FEV1/FVC. Table 1.Lung function and respiratory symptoms in obese and non-obese participants with preserved FEV1/FVC ratio.BMI 30(n=772)FEV1,% of predicted107.1 (16.1)101.8 (16.0)*FVC, % of predicted110.5 (14.8)103.5 (15.6)*Dyspnea (mMRC≥2)771 (31)458 (61)*Cough478 (19)169 (23)*Wheezing303 (12)111 (15)Sputum183 (7)109 (15)*Exacerbations383 (15)145 (19)**p
Introduction: Impairment in pulmonary functions and sleep related breathing disorders in patients with lipid storage disease (LSD) are unknown. We aimed to evaluate impairment in pulmonary functions and sleep related breathing disorders in patients with LSD.Methods: Pulmonary functions (FEV1, FVC, upright-supine %FVC change, MIP, MEP, PCF), arterial blood gas analysis (ABG) and polysomnography of patients with LSD were evaluated.Results: Twenty-five patients with LSD are evaluated [17 male, 8 female; age:34.9±15.02years, BMI:26.5±3.4kg/m2(19-31kg/m2)]. MIP:72.2±32.7cmH2O (
Conclusions: Commercial parasitoids may cause occupational asthma and rhinitis via IgE-mediated mechanism. Dosimeter seem to be more efficient method to deliver these allergens in the challenge than dusting.
Conclusion: FOB adds little to the diagnosis of chronic cough in the context of normal or non-localising CT findings. The diagnosis and treatment of chronic cough remains a challenge.
Conclusions In a sample of adults in a primary care setting, wheezing, male gender, and age>65 are predictors of AO. This should suggest to GPs to prescribe spirometry.
Background: Peak cough flow (PCF) measurement is used to estimate airway patency and bronchospasm during asthmatic exacerbations, as well as to determine expiratory muscle force in children with neuromuscular disorders. However, distrbution of PCF values in Greek pediatric population has not been thoroughly studied.Objective: The aim of this study is to investigate distribution of PCF values in Greek children and to correlate them with clinical and other spirometric parameters.Methods: A total of 101 healthy children 6-13 years old (41 girls, 60 boys) were clinically evaluated and spiromtered using a portable flow meter. P...
The aim of our study was to assess frequency of respiratory symptoms in reindeer herders, native population of peninsula Yamal.Six hundred reindeer herders (38.3% men) aged 30-54 yrs (mean age 42.2 yr), representing 34.0% of total population, participated in our cross-sectional survey.GARD questionnaire was used to analyze clinical symptoms. Upper airway diseases were excluded by the examination of ENT specialist.Pulmonary function was measured by dry spirometer (SpiroUSB ML 2525 CareFusion, UK) according to ATS/ERS criteria (2005).Response rate to the questionnaire was 97.0%. Eighty six percent of responders had respirato...
Conclusion: Treatment with mepolizumab is associated with an attenuated symptom response to prednisolone treatment in severe eosinophilic asthma via a mechanism that is likely to be independent of changes in airflow limitation.