Argonne X-rays used to help identify a key Lassa virus structure
(DOE/Argonne National Laboratory) Research done at Argonne National Laboratory's Advanced Photon Source was vital to the process of identifying the structure, which provides a guide for designing a Lassa virus vaccine. Lassa virus is endemic to Africa and kills thousands of people a year; it is particularly deadly for pregnant women.
Heart disease in pregnancy may manifest as acute coronary syndromes, decompensated valvular disease, and acute heart failure. These disease processes may represent progression of preexisting disease versus newly developed disease resulting from the physiologic changes of pregnancy. Early recognition of clinical presentations, judicious use of diagnostic studies, and multidisciplinary management of patient and fetal considerations can lead to optimal outcomes in this unique patient subset.
ConclusionsSubcutaneous immunotherapy with depigmented‐polymerized allergen extracts is a safe and clinically effective treatment for LAR to Phleum pratense.clinicaltrials. gov identifier: NCT02126111.This article is protected by copyright. All rights reserved.
Muslim leaders urge parents to vaccinate their children Cairo, 22 November – The Islamic Advisory Group for Polio Eradication (IAG) today launched a new training manual for students of religious studies in support of polio eradication efforts. The manual provides practical guidance on how to engage with local communities to advocate for vaccination as well as other maternal and child health issues. The launch took place during the group’s fourth annual meeting that convened at the headquarters of Al Azhar Al Sharif hosted by Grand Imam Dr Ahmed El-Tayyib. The Grand Imam expressed his happiness to see the pro...
Conclusions: “Histopathology consistent with CL” along with appropriate clinical findings supports the diagnosis of CL in an endemic area, and immunostains with CD1a Ab, clone MTB1, may help in the minority of the cases.
Over the years, academics have used all sorts of techniques during their shows at the Cabaret of Dangerous Ideas (CODI) —from music and props to experiments involving audience members. Yet, Dr Clare Taylor, Senior Lecturer in Medical Microbiology at Edinburgh Napier University, UK, is the first scientist I have seen who has started her show by tweeting. Taylor took to Twitter at the beginning of “Anti-vaxxers are antisocial” on Aug 12, 2017, to ask the US President, Donald Trump, “@realDonaldTrump a quick question, have your kids been vaccinated? @CODIfringe”.
In their thoughtful Personal View, Anika Singanayagam and colleagues1 raise several important questions relating to the apparent loss of efficacy of the live attenuated influenza virus (LAIV) vaccine. One factor not considered by the authors is the presence, in batches of the Fluenz Tetra vaccine (MedImmune, Nijmegen, Netherlands; AstraZeneca, Luton, UK) of substantial amounts of small RNAs derived from the genomes of both the influenza A and influenza B components of the vaccine itself.2 If the vaccine was composed only of infectious virus, one would expect to see only the eight full-length influenza segments of the viral A and B genomes.
We thank Nigel Dimmock and Andrew Easton for drawing attention to new research, which has become available since the publication of our article,1 describing their interesting observation of defective interfering RNAs in two batches of Fluenz Tetra (MedImmune, Nijmegen, Netherlands; AstraZeneca, Luton, UK) for the 2014 –15 influenza season.2 This research warrants further investigation to understand its implications.
GIDEON what’s new summary: November 21 to November 23, 2017 Infectious Diseases – Outbreaks (15 updates) 15 DiseasesMap Infectious Diseases – Diseases (112 updates) 50 Diseases62 Country notesMap Infectious Diseases – Drugs (1 updates) 1 Drug Infectious Diseases – Vaccines (1 updates) 1 New Vaccine Synonyms Added The post Update: November 23, 2017 appeared first on GIDEON - Global Infectious Diseases and Epidemiology Online Network.
Systemic lupus erythematosus: Effects of disease activity on pregnancy outcomes, Published online: 23 November 2017; doi:10.1038/nrrheum.2017.195Systemic lupus erythematosus: Effects of disease activity on pregnancy outcomes
Minatsu Kobayashi, Kohei Ogawa, Naho Morisaki, Yukako Tani, Reiko Horikawa, Takeo Fujiwara