Detroit research team to expand imaging technology to guide cancer treatment

(Wayne State University - Office of the Vice President for Research) A team of Wayne State University and Barbara Ann Karmanos Cancer Institute researchers recently received funding from the National Cancer Institute of the National Institutes of Health to expand the use of Positron Emission Tomography (PET) in cancer therapy.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Featuring Our Colorectal CAFSCAFs play a central role in the Tumor Microenvironment (TME). The TME has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, CAFs, a type of perpetually activated fibroblasts, have been implicated to have a strong tumor modulating effect and play a key role in areas such as drug resistance.This makes CAFs a target for cancer therapies. The challenge is the TME is heterogeneous making it a challenge to derive homogeneously relevant populations for basic research and drug discovery. This new study uses ourColorectal CAFs to identify...
Source: Neuromics - Category: Neuroscience Tags: CAFs Cancer Associated Fibroblasts CD90 colorectal CAFs Colorectal Cancer Flow cytometry PDGF Source Type: news
Researchers from the University of Wisconsin School of Medicine and Public Health have discovered a new way to measure the efficacy or failure of hormone therapy for breast cancer patients. A study detailing the findings was published in the February issue of The Journal of Nuclear Medicine. The findings showed that positron emission tomography (PET) imaging with 18F-fluorofuranylnorprogesterone (18F-FFNP) has been found to successfully measure changes in progesterone receptor (PR) levels resulting from a short-course estrogen treatment, also known as an estradiol challenge. Estrogen-receptor (ER)-positive breast cancer is...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news
Publication date: Available online 4 February 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Laleh Talavat, Ali GünerAbstractThe interaction dynamics between drug-monomer-solvent is the backbone of the thermodynamic calculation in molecular imprinting process and the controlled drug release components. In this regards, thermodynamic computational calculation was used for preparation of magnetic molecular imprinted polymers (MMIPs) and their subsequent application in the controlled release of 5-fluorouracil in the cancer therapy. Cohesive energy density of components (CED)/resolution parameters (δd, &de...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
AbstractPurpose of ReviewImaging modalities play an important role in the diagnosis and management of cardiotoxicity and cardiac tumors. In this review, we provide an overview of the imaging modalities that are relevant to the field of cardio-oncology.Recent FindingsCardiac magnetic resonance provides comprehensive tissue characterization in the assessment of cardiac tumors and cardiomyopathy. The combination of positron emission tomography/computed tomography offers improved localization of lesions, staging, targeting of biopsy and therapy, and greater confidence in interpretation.SummaryOverall, cardiac imaging plays a c...
Source: Current Radiology Reports - Category: Radiology Source Type: research
ConclusionsThe presence of RV wall uptake and the increase of SUV of RV wall on post-therapy PET/CT were associated with cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab. Oncologic FDG PET/CT scans can provide information regarding cancer therapy-induced cardiotoxicity as well as tumor response.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, hyaluronic acid (HA) conjugated bovine serum albumin (BSA) nanoparticles have been synthesized according to AmiNoAcid Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) that provides microemulsion polymerization at room temperature, under a nitrogen atmosphere in daylight. The synthesized nano BSA-HA particles have been characterized by Circular Dichroism (CD), Scanning Electron Microscopy (SEM), fluorescence spectrum and thermal gravimetric analysis. Then, nano BSA-HA particles have been used in vitro cytotoxicity analysis and imaging of PANC-1 ATCC® CRL146 cells. Cytotoxic effect of nano...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
CONCLUSION: In this population-based cohort of patients with incidental prostate cancer diagnosed at radical cystoprostatectomy, we found no impact of incidental prostate cancer on overall mortality, regardless of Gleason score, surgical margin status and pathological T-category. Patients diagnosed with incidental prostate cancer following radical cystoprostatectomy are unlikely to benefit from additional follow-up. PMID: 30624125 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Immune checkpoint therapies have shown tremendous promise in cancer therapy. However, tools to assess their target engagement, and hence the ability to predict their efficacy, have been lacking. Here, we show that target engagement and tumor-residence kinetics of antibody therapeutics targeting programmed death ligand-1 (PD-L1) can be quantified noninvasively. In computational docking studies, we observed that PD-L1–targeted monoclonal antibodies (atezolizumab, avelumab, and durvalumab) and a high-affinity PD-L1–binding peptide, WL12, have common interaction sites on PD-L1. Using the peptide radiotracer [64Cu]W...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 7 January 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Govindan Rajivgandhi, Seduraman Naveen kumar, Govindan Ramachandran, Natesan ManoharanAbstractMarine sponge alkaloid aaptamine is a promising anti-bacterial and anti-cancer drug against ESBL producing Gram negative bacteria and HepG 2 human liver carcinoma cell line. The antibacterial activity of aaptamine against selected ESBL producing Gram negative bacteria was inhibited at the concentration of 55 µg/mL. At the minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of 50 &micr...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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