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Detroit research team to expand imaging technology to guide cancer treatment

(Wayne State University - Office of the Vice President for Research) A team of Wayne State University and Barbara Ann Karmanos Cancer Institute researchers recently received funding from the National Cancer Institute of the National Institutes of Health to expand the use of Positron Emission Tomography (PET) in cancer therapy.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Yiwen Li, Huailin Yang, Jiuxu Yao, Haiyang Yu, Xin Chen, Peng Zhang, Chunsheng Xiao An amphiphilic biodegradable prodrug (PLG-g-mPEG/CPT) was synthesized by conjugating disulfide-containing camptothecin (CPT) to poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) through esterification reaction. The amphiphilic prodrugs could self-assemble into micellar nanoparticles and encapsulate doxorubicin (DOX) in aqueous solution at pH 7.4. The treatment of the nanoparticles with reducing glutathione (GSH) at c...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In this study, a promising drug nano-carrier system consisting of mono-dispersed and pH sensitive carboxylated chitosan-hollow mesoporous silica nanoparticles (Ccs-HMSNs) suitable for the treatment of malignant cells was synthesised and investigated. At neutral pH, the Ccs molecules are orderly aggregated state, which could effectively hinder the release of loaded drug molecules. However, in slightly acidic environment, Ccs chains are heavily and flexibly entangled in gel state, which would enhance the subsequent controlled release of the loaded drug. Using doxorubicin hydrochloride (DOX•HCl) as the drug model, their ...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Development and Evaluation of a Novel Drug Delivery: Soluplus®/TPGS Mixed Micelle Loaded With Piperine In Vitro and In Vivo. Drug Dev Ind Pharm. 2018 May 02;:1-20 Authors: Ding Y, Wang C, Wang Y, Xu Y, Zhao J, Gao M, Ding Y, Peng J, Li L Abstract BACKGROUND: Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and TPGS, to improve the aqueous solubility and anti-cancer effect. METHODS: Piperine -loaded mixed micelles were prepared using a thin- film hydration method, and th...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
CONCLUSION: The results provide strong rationale for further exploration of the newly developed CUR-SLN to be utilized as a potent chemotherapeutic agent in cancer therapy. PMID: 29732970 [PubMed - as supplied by publisher]
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Deliv Source Type: research
Positron Emission Tomography (PET) is the most specific and sensitive imaging technique for in vivo molecular targets and pathways, offering quantification and evaluation of functional properties of the targeted anatomy. This work is an integrative research review that summarizes and evaluates the accumulated current status of knowledge of recent advances in PET imaging for cancer diagnosis and treatment, concentrating on novel radiotracers and evaluating their advantages and disadvantages in cancer characterization.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Abstract In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Nitroxyl (HNO) has recently emerged as a prospective pharmacological agent.   Studies of the chemistry of HNO have led to an understanding that HNO is vastly different from nitric oxide (NO). HNO displays unique cardiovascular properties and has been shown to have positive effects in failing hearts without changing heart rate, and also has been shown to have beneficial eff ects in ischemia reperfusion injury.  In addition to the observed cardiovascular effects, HNO has shown initial promise in the realm of cancer therapy. HNO has been demonstrated to inhibit a key glycolytic enzyme. Due to the Warburg effect, inh...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
In this issue of Oncology Scan, similar to previous head and neck cancer Oncology Scans (1-7), we examine the use of genomic signatures to predict response to head and neck cancer therapy (8-10). In the past decade and a half, multiple teams have identified and developed gene expression profile signatures capable of subclassifying head and neck cancer, prognosticating outcome, and predicting treatment response. We discuss the implications of these genomic signatures for head and neck cancer patients, how these signatures can be applied to other therapies, their use to assist in preclinical studies, and suggestions on how t...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research
This study attested that pH-responsive thiol modified drug nanocarrier can have the potential cancer therapy. Graphical abstract
Source: Journal of the Taiwan Institute of Chemical Engineers - Category: Chemistry Source Type: research
Abstract Polymeric micelle-based drug delivery systems have dramatically improved the delivery of small molecular drugs, yet multiple challenges remain to be overcome. In this work, we engineered a polymeric nanomedicine that possesses an ultrahigh loading (59%) of a glutathione (GSH)-sensitive heterodimeric multifunctional prodrug (HDMP) to effectively co-deliver two synergistic drugs to tumor. Specifically, an HDMP comprising of chemotherapeutic camptothecin (CPT) and photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-α (HPPH), was conjugated via a GSH-cleavable linkage. The intrinsic fluorogen...
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research
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