Review: the re-emergence of brachytherapy as treatment for non-melanoma skin cancer.

Review: the re-emergence of brachytherapy as treatment for non-melanoma skin cancer. J Dermatolog Treat. 2017 Jun 12;:1-22 Authors: Ota K, Adar T, Dover L, Khachemoune A Abstract Electronic Brachytherapy (EBT) has seen a significant rise in use over the past few years in treating non-melanoma skin cancer (NMSC). However, the current literature in EBT remains scarce. Existing data on high dose rate brachytherapy (HDR-BT) with surface applicators is often used to justify its efficacy and safety. In this review we study the two treatment modalities on their efficacy in treating NMSC and we explore the reasons behind the recent uprise in EBT. A literature review using PubMed was performed for articles published until January 2017 studying efficacy of HDR-BT and EBT for treating NMSC. HDR-BT demonstrated effective local control ranging from 96.2% to 100% up to 66 months of follow-up with acceptable cosmesis. For EBT, local control rates ranged from 90% to 100% with generally favorable tolerance and cosmesis outcome after roughly one year. While longer term data on EBT is needed, its short term efficacy shows promise as a possible alternative to surgery or other radiation therapy in a select group of patients. PMID: 28604229 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Non-melanoma skin cancer (NMSC) is the most common cancer in fair-skinned adults and comprises basal-cell carcinoma (BCC) and squamous-cell carcinoma (SCC). Its incidence reaches 1/100 person-year in Australia (Lomas et al. 2012), and is still on the rise worldwide (Madan et al. 2010). Development of NMSC depends on genetic and environmental factors. Particularly, there is clear evidence that cumulative sun exposure contributes to the development of NMSC (Ananthaswamy et al. 1997; Madan et al. 2010).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
AbstractHuman papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are 5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV infections are typically asymptomatic or result in benign tumors, which may be disseminated or persistent in rare cases, but a few oncogenic HPVs can cause cancers. This review deals with the human genetic and immunological basis of interindividual clinical variability in the course of HPV infections of the skin and mucosae. Typical epidermodysplasia verruciformis (EV) is characterized by β-HPV-driven flat wart-like and pityriasis-lik...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Facial Plast Surg 2020; 36: 131-132 DOI: 10.1055/s-0040-1709120 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text
Source: Facial Plastic Surgery - Category: Cosmetic Surgery Authors: Tags: Guest Editor Preface Source Type: research
This article serves as a resource for optimal therapeutic decision making for surgical management of skin cancer on the face. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Facial Plastic Surgery - Category: Cosmetic Surgery Authors: Tags: Original Article Source Type: research
Facial Plast Surg 2020; 36: 200-210 DOI: 10.1055/s-0040-1709118There have been several significant advances in cancer treatment in the last decade that are applicable to the treatment of melanoma and advanced nonmelanoma skin cancers. Among these are the development of immune checkpoint inhibitors targeting the programmed death protein-1 (PD-1)/programmed death legand-1 (PDL-1) axis, as well as targeted inhibitors of the BRAF/MEK signaling cascade in melanoma, and the hedgehog signaling pathway in basal cell carcinoma (BCC). These immune-based and targeted therapies have dramatically changed the treatment options for local...
Source: Facial Plastic Surgery - Category: Cosmetic Surgery Authors: Tags: Original Article Source Type: research
Conclusions: Large databases are natural extension of traditional statistical approaches, a valuable and increasingly necessary tool for modern healthcare system. Future analysis of the collected multinational and multicenter data will show whether the use of the system can produce high-quality evidence to support multidisciplinary management of non-melanoma skin cancer and utilizing this information for personalized treatment decisions. PMID: 32395133 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
The objective of this paper was to review the literature regarding cutaneous manifestations associated with radiation therapy in order to promote awareness of the cutaneous radiation therapy-associated adverse effects. This extensive literature review was performed using the Pubmed and Embase databases. Studies were reviewed for relevance and critical evidence pertaining to cutaneous manifestations of radiation therapy. The most commonly reported cutaneous sequelae associated with radiation therapy include radiation dermatitis, non-melanoma skin cancer, radiation-associated angiosarcoma, morphea, bullous pemphigoid, lympha...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Abstract Ichthyosis with confetti (IWC) (OMIM#609165), also known as congenital reticular ichthyosiform erythroderma (CRIE), is an autosomal dominant genodermatosis with erythroderma on the entire body surface. Unique to IWC is the development of 100s and 1000s of pale spots resembling healthy skin. Almost 20% of the patients develop non-melanoma skin cancer (NMSC) in early adulthood for unknown reasons. In all the patients heterozygous variants in either keratin (KRT)10 or KRT1 have been found leading to a shifted reading-frame and translation of an aberrant carboxyl-terminus of the protein. PMID: 32407542 [...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
CONCLUSION: Our results suggest that 5-ALA-mediated sonodynamic therapy inhibited B16-F10 cell proliferation and melanoma-xenograft growth and prolonged survival of melanoma-bearing nude mice, which might be through downregulation of survivin expression. PMID: 32390599 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
The current COVID-19 pandemic is unprecedented in living memory and is affecting everyone, including our patients. It is increasingly important to provide the optimal management for patients with different non-melanoma skin cancers (NMSC). NMSC surgery has almost completely ceased over recent weeks. This is affecting already overstretched radiotherapy departments, with increasing numbers of patients being referred for definitive radiotherapy. Capacity and demand analysis and forecasting are taking place almost daily in radiotherapy departments across the UK in an attempt to manage this.
Source: Clinical Oncology - Category: Radiology Authors: Tags: Editorial Source Type: research
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