How Math Is Reshaping Mesothelioma Chemotherapy

This study demonstrates the feasibility of this approach since both preliminary encouraging signs of activity and no unexpected toxicities were observed, in this heavily pre-treated patients’ population.” Study Size and Rarity of Mesothelioma Present Challenges As a phase I clinical trial, it is a novel approach at this point but a promising step for future chemotherapy treatment plan protocols. The limited number of patients in the study — nine NSCLC and three mesothelioma — is also problematic, but the planned second phase of the study will include the new model’s effect on the immune system as well as additional data from other vinorelbine clinical trials. Barlesi said any possible differences in chemotherapy schedules between mesothelioma and NSCLC patients is “too difficult to say” at this point given the low number of mesothelioma patients in the phase I study. “At this time, we are focusing on tolerance, [pharmacokinetic] data and inter or intrapatients variability,” Barlesi said. “We’ll study preliminary efficacy and then decide if we should go to specific cohorts especially in mesothelioma patients.” The post How Math Is Reshaping Mesothelioma Chemotherapy appeared first on Mesothelioma Center - Vital Services for Cancer Patients &Families.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Aix-Marseille University anemia chemotherapy best vinorelbine regimen chemotherapy side effects Fabrice Barlesi low-dose oral chemotherapy drugs math cancer chemotherapy math to fight cancer mathematical modeling cancer mesothelioma chem Source Type: news

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In this study we tried to explore Diazepam as a repurposed drug and tested it in Neuroblastoma (Neuro 2a) cells. Diazepam loaded Poly Lactic Acid Nanoparticles were developed (D-PLA-NPs) using nanoprecipitation method. Entrapment efficiency was found to be ± 99.7% and drug loading was ± 12.88%. The particle size developed was 188.8 nm and zeta potential was −25.6 millivolt. Dissolution profiles were studied in PBS (pH 7.4) or simulated media, almost 50% release was observed within 6 h. In vitro, cytotoxicity was analyzed using MTT assay where dose-dependent cytotoxicity was observed for developed D-PLA-NPs.
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Abstract Two novel electrochemiluminescence (ECL) deoxyribosensors are designed for assay of early lung cancer biomarker (NAP2) using the DNA three-way junction (DNA-TWJ) inserted NAP2 binding aptamer between two double-helical stems and labeled with ruthenium (II) complex (Ru) (NBAT-Ru) taken as molecular recognition element. The signal-off ECL deoxyribosensor was fabricated by covalently coupling the 5'-NH2-(CH2)6-NBAT-Ru to glassy carbon electrode surface modified with 4-aminobenzoic acid (4-ABA). After combining NAP2 and NBAT-Ru, the changed conformation of NBAT-Ru altered the distance between Ru complex and e...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract The expression level of miRNA-21 is closely related to the occurrence and development of cancer, especially in gastrointestinal cancer. Monitoring miRNA-21 has clinical application in the diagnosis and evaluation of gastrointestinal cancer. A turn-on ratiometric fluorescence bioassay based on the T7 exonuclease-mediated cyclic enzymatic amplification method was developed for miRNA-21 determination by using carbon dots (CDs) and FAM-labeled ssDNA as the signal source. CDs demonstrated the triple functions of built-in internal fluorescence, probe carrier, and quencher in this strategy. In the absence of miR...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract Development of a mitochondria-targeting fluorescent probe with large Stokes shift and long-wavelength emission was benefit for accurate detection of hypoxic status, which was known as a major factor of the tumor physiology and influence important pathological processes. However, an efficient optical approach for simultaneously achieving such merits was still lacking. In this work, a turn-on fluorescence probe (HBT-NP) was designed to assess the hypoxic condition of tumor cells by detecting nitroreductase (NTR). Probe HBT-NP was constructed by conjugating 4-nitrobenzyl moiety as reaction site for NTR to 2-...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
This study provides a powerful approach for detection of highly reactive and unstable H2S biomolecules in live systems. PMID: 32081180 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Publication date: July 2020Source: Radiation Physics and Chemistry, Volume 172Author(s): A.S. Mustaqim, N.Z. Yahaya, N.N.A. Razak, H. ZinAbstractThe cancer treatment modalities have been developed rapidly with the aim to maximize the absorbed dose toward the cancer cells while sparing the healthy tissues. The use of high atomic number, Z nanomaterials has become interest as it offers the possibilities such as destroying cancer tumor with minimal damage to the healthy tissues. The study aimed to evaluate the role of methylene blue as it reduced the self-polymerization as well as to measure the dose enhancement effect of Zin...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
CONCLUSION: Repeat transoral laser microsurgery can be an oncologically safe alternative to other salvage therapies for glottic squamous cell carcinoma recurrence, without sacrificing functional outcomes. PMID: 32079549 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
CONCLUSIONS: Non-functional, metastatic Pan-NETs may transform to insulin secreting lesions, with negative impact on prognosis. Therefore, if symptoms as hypoglycemia develops continuous follow-up of clinical parameters, biochemical profiles of pancreatic hormones and histopathological evaluation of proliferation is suggested to detect changes in characteristics of these malignant neoplasms. PMID: 32087093 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Heba A. Hassan, Naglaa M. Ammar, Ahmed Serag, Olfat G. Shaker, Abdel Nasser El Gendy, Abdel-Hamid Z. Abdel-HamidAbstractColorectal cancer (CRC) is a major public health concern and one of the main causes of cancer-related deaths worldwide. Of different risk factors for developing CRC, obesity plays a vital key role in colorectal carcinogenesis due to the perturbation in the metabolic and lipid profiles of obese candidates. The aim of this study is to decipher the disturbed metabolites associated with CRC susceptibility in at-risk obese populatio...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Sirirat Boondireke, Chunyue Liu, Benjamas T. Wongsatayanon, Michèle Léonard, Alain DurandAbstractMonomyristin (MM), a monoacylglycerol with very low water solubility, has been reported to exhibit anti-proliferative property against cervical cancer cells. In order to increase its bioavailability, MM was encapsulated for the first time inside dextran-covered poly(lactic acid) nanoparticles. The use of dextran-based stabilizers with convenient structural characteristics was shown ...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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