Thalamus as a "hub" to predict outcome after epilepsy surgery

The role of the thalamus in mediating seizure activity has been investigated for decades.1 In 1952, Penfield2 proposed "centrencephalic" interactions as an integral part not only of generalized but also of focal automatisms. The dynamic integration between the centrencephalic system and cerebral cortex was hypothesized as pivotal for normal brain function, as well as a mechanism for seizure propagation. The concept was later hotly debated, and generalized seizures with 3-Hz spike wave discharges were considered mainly centrencephalic.1
Source: Neurology - Category: Neurology Authors: Tags: All Epilepsy/Seizures, Epilepsy surgery, Functional neuroimaging, Partial seizures EDITORIALS Source Type: research