Rapid focal cooling attenuates cortical seizures in a primate epilepsy model.

Rapid focal cooling attenuates cortical seizures in a primate epilepsy model. Exp Neurol. 2017 Jun 07;: Authors: Ren G, Yan J, Tao G, Gan Y, Li D, Yan X, Fu Y, Wang L, Wang W, Zhang Z, FengYue, Yang X Abstract Rapid focal cooling is an attractive nondestructive strategy to control and possibly prevent focal seizures. However, the temperature threshold necessary to abort seizures in primates is still unknown. Here, we explored this issue in a primate epilepsy model and observed the effect of rapid cooling on different electroencephalogram frequency bands, aiming at providing necessary experimental data for future clinical translational studies and exploring the mechanism of focal cooling in terminating seizures. We induced focal neocortical seizures using microinjection of 4-aminopyridine into premotor cortex in five anesthetized cynomolgus monkeys. The rapid focal cooling was implemented by using a thermoelectric (Peltier) device. As a result, the average durations of seizures and interictal intervals before cooling were 94.3±4.0s and 62.3±6.9s, respectively. When the cortex was cooled to 20°C or 18°C, there was no effect on seizure duration (109.4±30.0s, 91.3±19.3s) or interictal duration (99.4±26.8s, 83.2±11.5s, P>0.05). But when the cortex was cooled to 16°C, the seizure duration was reduced to 54.1±4.9s and the interictal duration was extended to 175.0±16.7s (P
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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Conclusion: The conclusion drawn from this systematic review will benefit the children with or without epilepsy undergoing sevoflurane anesthesia. Ethics and dissemination: Ethics approval is unnecessary because data of individual patients will not be included and no privacy will be involved. The results of this review will be published in a peer-reviewed journal or a conference report. Amendments of the basic protocol will be documented in the comprehensive review. PROSPERO registration number: PROSPERO CRD 42019122008.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Status epilepticus is a common neurological emergency, with overall mortality around 20%. Over half of cases are first time presentations of seizures. The pathological process by which spontaneous seizures are generated arises from an imbalance in excitatory and inhibitory neuronal networks, which if unchecked, can result in alterations in intracellular signalling pathways and electrolyte shifts, which bring about changes in the blood brain barrier, neuronal cell death and eventually cerebral atrophy.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Review Source Type: research
The most hidden corners of our bodies are exposed and manipulated by surgeons, then put back together again, all in the course of a morning or afternoon.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Epilepsy Seizures (Medical) Brain Surgery and Surgeons Anesthesia and Anesthetics Doctors Source Type: news
We describe the case of a 12-year-old girl who was diagnosed with DS and was scheduled to have gingival reduction around her mandibular molars. Despite the patient being intellectually disabled, she was able to cooperate somewhat during medical procedures, including intravenous cannulation. Under the assumption that the major problem with anesthesia for DS would be the regulation of body temperature-induced seizures, we used body temperature management equipment to maintain the patient's body temperature during the procedure. We opted for intravenous sedation and administered a total dose of 4.5 mg midazolam throughout the...
Source: Anesthesia Progress - Category: Anesthesiology Tags: Anesth Prog Source Type: research
ConclusionsThe incidence of PSE after mechanical thrombectomy was low in our cohort. All blood biomarkers displayed interesting sensitivity and specificity. However, the number of PSE cases was small and more studies are needed on risk factors for PSE after mechanical thrombectomy. The potential of blood markers of brain injury markers to contribute to assessment of PSE risk should be explored further.This article is part of the Special Issue "Seizures &Stroke".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Emma Christiaen, Marie-Gabrielle Goossens, Robrecht Raedt, Benedicte Descamps, Lars Emil Larsen, Erine Craey, Evelien Carrette, Kristl Vonck, Paul Boon, Christian VanhoveAbstractEpilepsy is a neurological disorder characterized by recurrent epileptic seizures. Electrophysiological and neuroimaging studies in patients with epilepsy suggest that abnormal functional brain networks play a role in the development of epilepsy, i.e. epileptogenesis, resulting in the generation of spontaneous seizures and cognitive impairment. In this longitudinal study, we...
Source: NeuroImage - Category: Neuroscience Source Type: research
r M Abstract OBJECTIVE: Fast track concepts are used to reduce the risk of perioperative and postoperative complications after total knee arthroplasty. INDICATIONS: The described concepts are used for patients with indications for the implantation of a total knee prosthesis. CONTRAINDICATIONS: Contraindications for fast track concepts are aged patients, dementia, American Society of Anesthesiologists (ASA) grade IV and implantation of large revision or tumor prostheses. Contraindications for tranexamic acid are bleeding in the urinary tract, caution in cases of known epilepsy, individual risk assessment ...
Source: Operative Orthopadie und Traumatologie - Category: Orthopaedics Authors: Tags: Oper Orthop Traumatol Source Type: research
CONCLUSIONS: The incidence of PSE after mechanical thrombectomy was low in our cohort. All blood biomarkers displayed interesting sensitivity and specificity. However, the number of PSE cases was small and more studies are needed on risk factors for PSE after mechanical thrombectomy. The potential of blood markers of brain injury markers to contribute to assessment of PSE risk should be explored further. This article is part of the Special Issue "Seizures &Stroke". PMID: 31526644 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
This study aimed to investigate the role of xenon inhalation and explore the role of different xenon ratio gradients and different delayed treatment times in seizure models. Kainic acid (KA)-induced status epilepticus and neonatal hypoxia-induced seizure models were used in our study. Animals were subject to inhalation of xenon mixture for 60 min after the stimulation used to induce seizures. The control group was treated with 70% nitrogen/30% oxygen, as in previous reports. Behavioral changes, electroencephalography, neuronal injury, and learning and memory function were investigated in each group. The results indicate ...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
Conclusions: Our experience suggests that intranasal dexmedetomidine is an advantageous sedation option for children and adults with intractable epilepsy who are undergoing MEG. Further research is needed to determine the best ways to apply these methods to younger children and those with developmental disabilities.
Source: Journal of Clinical Neurophysiology - Category: Neurology Tags: Original Research Source Type: research
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