Isolated Abducens Palsy Heralding Occult Human Immunodeficiency Virus –Related Lymphoma

.
Source: Neuro-Ophthalmology - Category: Opthalmology Authors: Source Type: research

Related Links:

Hypoxic injury is one of the most important factors in progressive kidney disorders. Since we have found that δ-opioid receptor (DOR) is neuroprotective against hypoxic stress through a differential regulation of mitogen-activated protein kinases (MAPKs) and anti-inflammatory cytokines, we asked if DOR that is highly expressed in the kidney can modulate renal MAPKs and anti-inflammatory cytokines under hypoxia. We exposed cultured rat kidney epithelial cells (NRK-52E) to prolonged hypoxia (1% O2) with applications of specific DOR agonist or/and antagonist to examine if DOR affects hypoxia-induced changes in MAPKs and...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionsOnly patients with earliest ‐stage EHM detected shortly before LDLT are indicated for upfront LDLT combined with peritransplant EHM treatment.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
SummaryAnaplastic lymphoma kinase (ALK), which belongs to the insulin receptor tyrosine kinase superfamily, plays an important role in nervous system development. Due to chromosomal translocations, point mutations, and gene amplification, constitutively activated ALK has been implicated in a variety of human cancers, including anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer, and neuroblastoma. We evaluated the anti-cancer activity of the ALK inhibitor KRCA-0008 using ALCL cell lines that express NPM (nucleophosmin)-ALK. KRCA-0008 strongly suppressed the proliferation and survival of NPM-ALK-positive ALCL ...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Bone Marrow Transplantation, Published online: 20 January 2020; doi:10.1038/s41409-020-0789-5Intensive chemotherapy and up-front stem cell transplant for double hit lymphoma
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Holmes Barrs Beatty Papillomaviruses infect the skin and mucosal surfaces of diverse animal hosts with consequences ranging from asymptomatic colonization to highly malignant epithelial cancers. Increasing evidence suggests a role for papillomaviruses in the most common cutaneous malignancy of domestic cats, squamous cell carcinoma (SCC). Using total DNA sequencing we identified a novel feline papillomavirus in a nasal biopsy taken from a cat presenting with both nasal cavity lymphoma and recurrent squamous cell carcinoma affecting the nasal planum. We designate this novel virus as Felis catus papillomavirus 6 ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: Available online 18 January 2020Source: Gynecologic Oncology ReportsAuthor(s): Bijan Morshedi, Kari RingAbstractPemphigus is a group of autoimmune intraepidermal blistering diseases caused by immunoglobulins directed against keratinocyte cell surface components. In this case report, we identify a non-classical paraneoplastic pemphigus (PNP) foliaceous related to an undifferentiated uterine sarcoma.The patient is a 54-year-old female with a past medical history of arthritis who presented with worsening fatigue in November 2017 and an itchy, blistering, erythematous annular plaque that first appeared on her...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: March 2020Source: Molecular Immunology, Volume 119Author(s): Yasuyuki Otsuka, Momoko Nishikori, Hiroshi Arima, Kiyotaka Izumi, Toshio Kitawaki, Masakatsu Hishizawa, Akifumi Takaori-KondoAbstractLoss of CD58 is a common mechanism for tumor immune evasion in lymphoid malignancies. CD58 loss is known to occur due to both genetic and non-genetic causes; therefore, we hypothesized that restoring CD58 expression in lymphoma cells may be an effective treatment approach. To explore the potential for restoring CD58 expression, we first screened 11 B-cell lymphoma lines and found that 3 had decreased CD58 expressio...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Salvage chemotherapy (often with rituximab and radiotherapy), followed by HDT and stem cell transplantation, appears to be the standard real-world treatment for rrPMBCL. However, large prospective and retrospective studies are warranted to improve our knowledge of real-world treatment patterns. PMID: 31951774 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Güemes-Villahoz N, Burgos-Blasco B, Moreno-Morillo FJ, Troyano-Rivas JA PMID: 31948686 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Joseph McMullan, 31, has a type of lymphoma - cancer of the lymphatic system, which is part of the immune system. He was eligible for the treatment and felt optimistic.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Brain | Lymphoma | Neurology | Opthalmology