Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reacti...
Source: Malaria Journal - Category: Infectious Diseases Authors: Source Type: research

Related Links:

Date: Tuesday, 11 26, 2019; Speaker: Susan Pierce, Ph.D., Chief, Laboratory of Immunogenetics, NIAID; Building: 35; GF640
Source: NIH Calendar of Events - Category: American Health Source Type: events
Publication date: Available online 22 October 2019Source: Antiviral ResearchAuthor(s): Esther Oiknine-Djian, Shikma Bar-On, Ido Laskov, Daniel Lantsberg, Richard K. Haynes, Amos Panet, Dana G. WolfAbstractWe have recently shown that the artemisinin derivative artemisone, which was screened against malaria in human clinical studies, is a potent inhibitor of human cytomegalovirus (HCMV). Here we evaluated the antiviral effect of artemisone when employed in 2-drug combinations with approved and experimental anti-HCMV agents. Using the Chou-Talalay method, we found that in-vitro combination of artemisone with cidofovir, brinci...
Source: Antiviral Therapy - Category: Virology Source Type: research
[Global Fund] Lyon, France -At the opening of the Sixth Replenishment conference, the Global Fund announced a range of private sector partners that will spur innovation to accelerate the end to HIV, tuberculosis and malaria, the world's deadliest infectious diseases.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Daily Trust] The Federal Government has pledged $12 million to the Global Fund to tackle HIV, tuberculosis and malaria.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
Human movement into insect vector and wildlife reservoir habitats determines zoonotic disease risks; however, few data are available to quantify the impact of land use on pathogen transmission. Here, we utilise GPS tracking devices and novel applications of ecological methods to develop fine-scale models of human space use relative to land cover to assess exposure to the zoonotic malariaPlasmodium knowlesi in Malaysian Borneo. Combining data with spatially explicit models of mosquito biting rates, we demonstrate the role of individual heterogeneities in local space use in disease exposure. At a community level, our data in...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Source Type: research
Conclusions: Naturally acquired sexual stage immunity, as detected by antibodies to Pfs230 and Pfs48/45, was present in most studies analyzed. Significant between-study heterogeneity was seen, and methodological factors were a major contributor to this, and prevented further analysis of epidemiological and biological factors. This demonstrates a need for standardized protocols for conducting and reporting seroepidemiological analyses.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractA major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method for drug target deconvolution inPlasmodium falciparum is in vitro evolution of compound-resistant parasites followed by whole-genome scans. Several of the most promising antimalarial drug targets, such as translation elongation factor 2 (eEF2) and phenylalanine tRNA synthetase (PheRS), have been identified or confirmed using this method. One drawback of this method is that if a mu...
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
NPR was the only news organization allowed into the lab to witness the moment the releases began this year. The goal is to create a powerful new weapon in the fight against malaria.(Image credit: Pierre Kattar for NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
In this study, we carried out qualitative and quantitative analysis of the donkey whey proteome using a label-free proteomic approach, combined with parallel reaction monitoring (PRM) as a validation method. A total of 300 whey proteins were identified in donkey colostrum (DC) and donkey mature (DM) milk, of which 18 were differentially expressed (P
Source: Food Research International - Category: Food Science Source Type: research
Conclusions: ivA was highly efficacious in this pediatric cohort. We observed episodes of mild to moderate posttreatment hemolysis in approximately one-third of patients. The legal status and usage of potentially lifesaving ivA should be evaluated in Europe.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
More News: Infectious Diseases | Malaria | Study