Pemphigus Vulgaris Persistently Localized to the Nose with Local and Systemic Response to Topical Steroids.

Pemphigus Vulgaris Persistently Localized to the Nose with Local and Systemic Response to Topical Steroids. Acta Derm Venereol. 2017 Jun 09;: Authors: Zhang C, Goldscheider I, Ruzicka T, Sárdy M PMID: 28597020 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin. The pathomechanism of blister formation in PF is unknown. Previously we have shown that PF IgG induces aggregation of DSG1, plakoglobin (PG), and IgG outside of desmosomes, what in immunofluorescence of PF patient skin visualizes as a granular IgG deposition pattern with a limited number of coarse IgG aggregates between cells. Here we have investigated the fate of these aggregates in skin and found that these are cleared by endocy...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
(University of Pennsylvania School of Medicine) Researchers from Penn compare a lymphoma-dose regimen of rituximab to a rheumatoid arthritis regimen for the treatment of pemphigus.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Mihika Dube, Brijesh Takkar, Dinesh P Asati, Sourabh JainIndian Journal of Dermatology 2019 64(6):499-500
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
This study aims to identify which disease severity index correlates best with the change in QOL. Fifty pemphigus patients completed QOL surveys with disease severity scored over two visits. QOL was assessed with the Autoimmune Bullous Disease Quality of Life (ABQOL), Dermatology Life Quality Index (DLQI), Skindex-29, and Short Form Survey 36 (SF-36). Disease severity was scored with the Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). Correlations between the change in QOL scores and change in disease severity were analyzed using Spearman's coefficient (r). The change in PDA...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: Firmicutes phylum and Staphilococcus genus were the most represented in OM and CM swabs of PV and BP microbial populations. Moreover, we argue the quantitative imbalance linked to the decrease of Bacteriodetes in the oral cavity of PV patients might be associated to disease typical fetor. To shed light on this peculiar feature further studies are still required. PMID: 31705881 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
CONCLUSIONS: First-line treatment of pemphigus with rituximab results in a slightly greater cost compared with a standard CS regimen. PMID: 31657454 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Interview with Aimee S. Payne, MD, PhD, author of Factors Associated With Complete Remission After Rituximab Therapy for Pemphigus
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts
This cohort study evaluates the association between use of rituximab and remission in patients with pemphigus.
Source: JAMA Dermatology - Category: Dermatology Source Type: research
Mucocutaneous diseases affecting the oral cavity are predominantly immune mediated or inflammatory. Three of the most common and clinically significant conditions are reviewed in this article: lichen planus, pemphigus vulgaris, and mucous membrane pemphigoid. Because oral manifestations may be the first or only manifestation of mucocutaneous diseases, oral health professionals play a critical role in the early diagnosis and multidisciplinary management of these conditions.
Source: Dental Clinics of North America - Category: Dentistry Authors: Source Type: research
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