Making serine integrases work for us.

This article summarizes our current knowledge of serine integrase structure and mechanism, then outlines key factors that affect the performance of these phage recombination systems. Recently published studies, that have expanded the repertoire of available systems and reveal system-specific characteristics, will help us to choose the best integrases for envisaged applications. PMID: 28599144 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

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Condition:   Methylmalonic Acidemia Intervention:   Biological: hLB-001 Sponsor:   LogicBio Therapeutics, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Researchers here report on an interesting proof of concept, incorporating electronic device capabilities into the flexible biomaterials used as scaffolding for blood vessel tissue engineering. As a next generation technology to potentially replace the use of stents in the treatment of cardiovascular disease, bioartificial blood vessel sections are already promising. Adding to this the programmable ability to alter nearby cell behavior, control delivery of gene-based therapeutics, or report sensory data on cells and blood flow opens up intriguing new vistas for the future. A variety of tissue-engineered blood vesse...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(Mary Ann Liebert, Inc./Genetic Engineering News) The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation. CF clinical trials showing that a genotype-agnostic gene therapy for CF is possible
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Congenital enteropathies comprise a heterogeneous group of disorders typically resulting in severe diarrhea and intestinal failure. Recent advances in and more widespread application of genetic testing have allowed more accurate diagnosis of these entities as well as identification of new disorders, provided a deeper understanding of intestinal pathophysiology through genotype-phenotype correlations, and permitted the exploration of more specific therapies to diseases that have heretofore been resistant to conventional treatments. The therapeutic armamentarium for these disorders now includes intestinal and hematopoietic s...
Source: Surgical Pathology Clinics - Category: Pathology Authors: Source Type: research
NEW YORK&BRISBANE, Calif.--(BUSINESS WIRE) October 07, 2020 -- Pfizer Inc. (NYSE: PFE) and Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicines company, today announced that the first participant has been dosed in the Phase 3 AFFINE...
Source: Drugs.com - Clinical Trials - Category: Pharmaceuticals Source Type: clinical trials
Publication date: 2020Source: Computational and Structural Biotechnology Journal, Volume 18Author(s): Yuanyuan Xu, Zhanjun Li
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Authors: Tsai JC Abstract While sustained reduction of intraocular pressure (IOP) has been shown to halt and/or delay the progressive death of retinal ganglion cells (RGCs) in glaucoma, there exists great interest in the development and validation of IOP-independent therapeutic strategies for neuroprotection and/or neuroregeneration. Multiple etiologies for RGC death have been implicated in glaucoma including defective axonal transport, ischemia, excitotoxicity, reactive oxygen species, trophic factor withdrawal, and loss of RGC electrical activity. However, IOP lowering with medical, laser, and surgical therapies ...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Researchers based in China and Switzerland have jointly developed electrically conductive artificial blood vessels that may serve as implants to replace diseased native vessels. The flexible and biodegradable constructs consist of a metal-polymer con...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Thoracic Surgery Vascular Surgery Source Type: blogs
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare congenital arrhythmogenic disorder induced by physical or emotional stress. It mainly affects children and younger adults and is characterized by rapid polymorphic and bidirectional ventricular tachycardia. Symptoms can include dizziness, palpitations, and presyncope, which may progress to syncope, hypotonia, convulsive movements, and sudden cardiac death. CPVT is the result of perturbations in Ca2+ ion handling in the sarcoplasmic reticulum of cardiac myocytes. Mutations in the cardiac ryanodine receptor gene and the calsequestrin isoform 2 gene are mo...
Source: Cardiology in Review - Category: Cardiology Tags: Invited Review Articles Source Type: research
(Alliance for Cancer Gene Therapy) Alliance for Cancer Gene Therapy (ACGT) gives $500,000 research grant to Sidi Chen, Ph.D., with Yale School of Medicine and Yale Cancer Center to advance strategies for treating pancreatic cancer
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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