Tuning in to Sympathetic Activity Cutaneously in Humans: A Bench to Bedside Saga

Sympathetic nervous system regulation plays a crucial role in health and disease. Practically all major organs are subject to sympathetic influences and when autonomic dysfunction occurs, pathologic consequences can be dire. Abnormalities in sympathetic tone have been implicated in the pathogenesis of atrial and ventricular arrhythmias, myocardial infarction, heart failure, epilepsy, renal failure, hypertension, stroke, and diabetes, as well as other disease conditions [1 –3]. Recognition of this linkage across the decades has provided a significant impetus to develop reliable methods to monitor sympathetic tone in order to gain deeper insights into mechanisms of disease.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research

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ConclusionsOur study provides fundamental insights on the molecular mechanisms underlying POMC neuron malprogramming in obesogenic contexts.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 16 February 2020Source: Canadian Journal of DiabetesAuthor(s): Tomoyuki Kawada
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
This article aims to classify the severity grading assessments for both insulin resistance (IR) syndrome and status of pancreatic beta (β) islet cells’ function using the homeostasis model assessment method (that is; homeostasis model assessment-insulin resistance [HOMA-IR] and homeostasis model assessment-pancreatic beta (β) islet cells’ function [HOMA-B] indices) with the focus of disseminating this information rapidly for clinical use by physicians in their patients with dysfunctional regulation of glucose metabolism. It will also assist clinicians to prevent and screen for these individuals who ar...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
In this study, the core-shell polydopamine-coated magnetic nanomaterials were synthesized with one-step approach and applied as magnetic solid phase extraction adsorbents combined with LC-MS/MS for quantification of the diabetes drug glimepiride in beagle dog plasma. The Fe3O4@PDA nanomaterials have strong magnetic response, good dispersibility in aqueous solution, and numerous binding sites for π–π interaction and hydrogen bonding with glimepiride. Based on these merits, glimepiride could be quickly extracted and separated from plasma within 10min. The established method has good linearity (1-2000ng•mL-1)...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Authors: Boivin JM, Risse J, Laurière E, Burnier M Abstract Purpose: Worldwide, hypertension awareness remains largely insufficient. This is particularly true in some population subgroups with a low socioeconomic status or in young adults who have limited interactions with healthcare systems. Performing Blood Pressure (BP) screening in non-conventional settings, such as in barbershops, has been suggested by a number of American authors. Whether this approach is feasible in Europe or in North Africa has not been evaluated, however. We, therefore, undertook a study to assess the value of BP screening at hairdr...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbe A Abstract Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. From an etiological point of view, the diagnosis of the arteritic form due to giant cell arteritis requires emergent management to prevent blindness and even death in the absence of prompt corticosteroid treatment. When this diagnosi...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Publication date: Available online 15 February 2020Source: Clinica Chimica ActaAuthor(s): Yao-Chang Liu, Jen-Pi Tsai, Li-Hsuan Wang, Ming-Che Lee, Bang-Gee HsuAbstractBackgroundFibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients.MethodsThe fasting blood samples of RT recipients (n=66) were collected and analyzed.ResultsA total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a hig...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
DiscussionSetting optimized thyrotropin cutoffs for reflex testing of free thyroxine would reduce the need for this test. Clinical laboratories need to offer not only true results, but also become the cornerstone in the optimization of resources.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
DiscussionDystrophin deficiency likely disrupts Octn2 expression decreasing muscle carnitine uptake thus contributing to membranotoxic long-chain acyl-CoAs with sarcolemmal and organellar membrane oxidative injury providing a treatment rationale for early L-carnitine in DMD.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
We report the case of a female who sought medical help for malabsorptive symptoms and was finally diagnosed with olmesartan-associated gastritis and atrophic enteropathy. PMID: 32054274 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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