Cutaneous Nerve Biomarkers in Transthyretin Familial Amyloid Polyneuropathy

Conclusion: Cutaneous amyloid was detected in 70% of TTR‐FAP and 20% of TTR‐noPN subjects. Amyloid burden correlated strongly with reductions in IENFD, SGNFD, PMNFD and NIS‐LL. Skin is an attractive tissue to establish an amyloid diagnosis and amyloid burden has potential as a biomarker to detect treatment effect in TTR‐FAP drug trials. This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fana.24972

Source: Annals of Neurology - May 1, 2017 Category: Neurology Authors: Gigi J Ebenezer, Ying Liu, Daniel P. Judge, Kelly Cunningham, Shaun Truelove, Noel D. Carter, Blessan Sebastian, Kelly Byrnes, Michael Polydefkis Tags: Research Article Source Type: research