Tourette ’s Syndrome and Comorbid Neurological Condition

AbstractTourette syndrome (TS) often presents with other comorbid conditions in clinical settings. The most common comorbidities are obsessive-compulsive disorder or obsessive-compulsive behaviors, attention deficit hyperactivity disorder, learning disabilities, autism, mood and anxiety disorders, and personality disorders. Comorbid disorders and coexistent psychopathologies are often associated with impaired functioning, more severe course, and poorer long-term outcome. The overall presentation of TS with and without comorbidities can be significantly different and comorbid neuropsychiatric conditions may also change with age. Thus, frequent reassessment of symptoms and re-ordering of treatment priorities are needed when following the child over the developmental timeline.
Source: Current Developmental Disorders Reports - Category: Child Development Source Type: research

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Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Public Health Source Type: research
CONCLUSIONS: Serum and exosomal hsa_circ_0000907 and hsa_circ_0057362, especially hsa_circ_0000907, have novel diagnostic capabilities in the early diagnosis of DFU. PMID: 32767340 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Our study demonstrated evidences to support the safety and effectiveness of BMAC transplantation in the management of autism. PMID: 32767334 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Abstract Neurosarcoidosis (NS) is an often severe, destructive manifestation with a likely under-reported prevalence of 5 to 15% of sarcoidosis cases, and in its active phase demands timely treatment intervention. Clinical signs and symptoms of NS are variable and wide-ranging, depending on anatomical involvement. Cranial nerve dysfunction, cerebrospinal parenchymal disease, aseptic meningitis, and leptomeningeal disease are the most commonly recognized manifestations. However, non-organ-specific potentially neurologically driven symptoms, such as fatigue, cognitive dysfunction, and small fiber neuropathy, appear ...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Semin Respir Crit Care Med Source Type: research
Publication date: Available online 12 August 2020Source: Journal of Anxiety DisordersAuthor(s): Matthew T. Tull, Anna C. Barbano, Kayla M. Scamaldo, Julia R. Richmond, Keith A. Edmonds, Jason P. Rose, Kim L. Gratz
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Publication date: November 2020Source: Neuroscience &Biobehavioral Reviews, Volume 118Author(s): Maja Dobrosavljevic, Carmen Solares, Samuele Cortese, Henrik Andershed, Henrik Larsson
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
CONCLUSION: These findings provide additional evidence for dysregulation of the blood-brain barrier, especially abnormalities in claudin-5 function, which may be involved in the aetiology of ADHD. Key points ADHD is one of the most common neurodevelopmental disorders of childhood. Although ADHD is quite common, its aetiology has yet to be fully explained. In recent years, studies on the relationship between intestinal and blood-brain brain barrier permeability and psychiatric disorders have increased. In our study, serum claudin-5 levels were higher in the ADHD group compared to the control group, while serum zonulin level...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
This study indicated that the COMT rs4680 genotype might not be related to GAD or to the genders of the GAD patients, nor did it have any effect on the antidepressant therapeutic response in the GAD patients. Even so, our research will be helpful by providing guidance and direction for future, more in depth, research. PMID: 32782694 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
Purpose of review Breathlessness is a prevalent and aversive symptom in various conditions and closely related to affect. Here, we review recent literature from the previous 18 months examining the interactions between affective traits and states with breathlessness. Recent findings Available studies used various qualitative, quantitative, and experimental research designs in diverse samples of patients with breathlessness and in healthy individuals. Most studies clearly demonstrated that nonspecific forms of negative affective personality traits such as anxiety and depression, disease or symptom-specific forms such a...
Source: Current Opinion in Supportive and Palliative Care - Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research
Authors: Fang JW, Yu YJ, Tang LY, Chen SY, Zhang MY, Sun T, Wu SN, Yu K, Li B, Shao Y Abstract BACKGROUND We used fractional amplitude of low-frequency fluctuation (fALFF) technology to investigate spontaneous cerebral activity in patients with monocular blindness (MB) and in healthy controls (HCs). MATERIAL AND METHODS Thirty MB patient and 15 HCs were included in this study. All subjects were scanned by resting-state functional magnetic resonance imaging (rs-fMRI). The independent sample t test and chi-squared test were applied to analyze demographics of MB patients and HCs. The 2-sample t test and receiver opera...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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