Environmental Exposures to Lead, Mercury, and Cadmium and Hearing Loss in Adults and Adolescents: KNHANES 2010 –2012

We examined the association between environmental exposures to lead, mercury, and cadmium and the risk of hearing loss in adults and adolescents while controlling for potential confounding factors, including noise exposures and clinical factors. Methods: We analyzed cross-sectional data from 5,187 adults and 853 adolescents in the Korean National Health and Nutrition Examination Survey 2010–2012. Pure-tone average (PTA) of hearing thresholds at high frequency (3, 4, and 6 kHz) were computed, and hearing loss was defined as a PTA>25 dB in adults and PTA>15 dB in adolescents. Results: In adults, the highest (vs. lowest) quartiles of blood lead and cadmium were associated with 1.70 (95% CI: 1.25, 2.31) and 1.47 (95% CI: 1.05, 2.05) odds ratios for high-frequency hearing loss (p-trend25 dB in either ear [World Health Organization/International Repository for Information Sharing (Informal Working Group on Prevention of Deafness and Hearing Impairment Programme Planning) 1991]. Because adolescents have greater hearing sensitivity, adolescent hearing loss was defined as a PTA>15 dB in either ear (Niskar et al. 1998; Shargorodsky et al. 2010). Determination of Lead, Mercury, and Cadmium in Blood Blood samples for lead, mercury, and cadmium measurements were drawn into trace-metal-free ethylenediaminetetraacetic acid (EDTA) tubes, and specimens were immediately transferred at 2–8°C to a central laboratory for analysis (NeoDin Medi...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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CONCLUSIONS: Based on these results, 8.1% of Mexican general population without a history of liver disease is at high risk of having advanced liver fibrosis and complications and death derived from cardiovascular disease and cirrhosis. Most of them showed normal ALT serum levels. PMID: 32063504 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Authors: Meunier L, Larrey D Abstract Some drugs may induce hepatotoxic lesions, such as steatosis or steatohepatitis found in Non-Alcoholic Fatty Liver Disease (NAFLD). Among these drugs there are some anti-tumoral molecules, such as methotrexate, 5-fluorouracil, irinotecan, tamoxifen and l-asparaginase. The hepatotoxic phenotype developed from treatment with such drugs is known as "CASH" for "Chemotherapy-induced Acute Steatohepatitis". The mechanism of toxicity is essentially based on mitochondrial toxicity. These lesions are chronic and often reversible when the treatment is stopped. Contrib...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
The objective of this research article was to assess the trend of hospitalization, epidemiological characteristics and economic burden in the young adult, aged 18–45 years, presenting with atrial fibrillation.MethodsHospitalization data from the National Inpatient Sample between 2005 and 2015 were used to analyze prevalence of risk factors and financial burden in young adults with atrial fibrillation.ResultsFrom 2005 to 2015, a total of 260,080 admissions were included in the study. From 2005 to 2015, there was a decreasing trend of total admissions with atrial fibrillation among the age group of 18–45 years co...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
A 92-year-old woman with a foreign body perforation of the esophagus underwent esophageal repair and esophageal stent placement. A computed tomography (CT) scan of the chest performed for worsening leukocytosis demonstrated an enlarging air-containing mediastinal collection despite a surgically placed mediastinal drain; interventional radiology was consulted. The 3-day-old anteriorly placed drain had a long infracardiac course, and drain exchange was believed to be too high risk for loss of access.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Extreme IR Source Type: research
Publication date: Available online 17 February 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Gulim Murzakanova, Sari Räisänen, Anne Flem Jacobsen, Kristina Baker Sole, Lisa Bjarkø, Katariina LaineAbstractObjectiveTo assess the prevalence and risk of adverse perinatal outcomes in early-term (37+0–38+6 weeks), full-term (39+0–40+6 weeks), late-term (41+0–41+6 weeks), and post-term (>42+0 weeks) deliveries with spontaneous labor onset.Study designA population-based cohort with data from the Medical Birth Registry Norway (MBRN) and Statistics...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
No abstract available
Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Cochrane Nursing Care Corner Source Type: research
No abstract available
Source: The Nurse Practitioner - Category: Nursing Tags: Department: Guest Editorial Source Type: research
In what ways might obesity impact liver enzyme concentrations in the pediatric population?Journal of Clinical Endocrinology &Metabolism
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
SGLT2 inhibitors are commonly used in the treatment of type 2 diabetes, but what do we know about the renal effects of these drugs?Current Opinion in Nephrology and Hypertension
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
Prehydrating patients who have chronic kidney disease before they undergo a...Read more on AuntMinnie.comRelated Reading: Experts reaffirm safety of contrast use for kidney CT Could patient history help predict CT contrast reactions? Oral contrast not needed to spot kids' appendicitis on CT Contrast use doesn't change acute kidney injury rate CT contrast not tied to poor outcomes, even in at-risk patientsComments: 2/18/2020 6:19:39 PMChris Woodhouse You guys are driving me crazy!  Just when I get the clinic settled into the practice of pushing clear fluids before any contrast study, you tell me it doesn't ...
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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