Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice

Conclusion:
CYP2F1 is an active enzyme. Both CYP2A13 and CYP2F1 are active toward NA in the CYP2A13/2F1-humanized mice, where they play significant roles in NA-induced respiratory tract toxicity. https://doi.org/10.1289/EHP844

Received: 20 July 2016
Revised: 22 October 2016
Accepted: 07 November 2016
Published: 08 June 2017
Address correspondence to L. Van Winkle, Center for Health and the Environment, Building 3792, Room 129, Old Davis Rd., UC Davis, Davis, CA 95616 USA. Telephone: [phone]. E-mail: [e-mail] , and X. Ding, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Rd., NanoFab East, Albany, NY 12203 USA. Telephone: [phone]. E-mail: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP844).
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - June 9, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research