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The Role of the Corpus Callosum in Pediatric Dysphagia: Preliminary Findings from a Diffusion Tensor Imaging Study in Children with Unilateral Spastic Cerebral Palsy

AbstractThe purpose of this study is to determine the relationship between the structural integrity of the corpus callosum (CC) and clinical feeding/swallowing performance in children with unilateral spastic cerebral palsy (USCP). Twenty children with USCP, (11 males, 5.11 –17.6 yoa) were assessed via the Dysphagia Disorder Survey (DDS) and diffusion tensor imaging. Children were grouped into left hemisphere lesion (LHL;n = 13) and right hemisphere lesion (RHL;n = 7) groups. DTI variables analyzed for three CC regions (anterior, middle, posterior) were: fractional anisotropy (FA), radial diffusivity (RD), mean diffusivity (MD), and fibers count. Children with RHL presented with higher clinical dysphagia severity (p = 0.03). Six of seven children with RHL had lesions affecting periventricular/subcortical areas, and 8/13 children with LHL had lesions affecting the sensorimotor cortex. In the LHL group, as FA and fiber count of the anterior CC decreased and RD increased (all indicating reduced CC structural in tegrity), signs of dysphagia increased (r = −0.667,p = 0.013;r = −0.829,p ≤ 0.001;r = 0.594,p = 0.032, respectively). Reduced fiber count in the middle and posterior CC was also significantly associated with increased DDS scores (r = −0.762,p = 0.002;r = −0.739,p = 0.004, respectively). For the RHL group no ...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Condition:   Cerebral Palsy Spastic Diplegia Intervention:   Behavioral: Short Burst Interval Locomotor Treadmill Training (SBLTT) Sponsors:   Seattle Children's Hospital;   Louisiana State University Health Sciences Center in New Orleans Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories Center for Advanced Intestinal Rehabilitation cerebral palsy Dr. Christopher Duggan Dr. Mark Puder Dr. Tom Jaksic necrotizing enterocolitis short bowel syndrome (SBS). Source Type: news
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AimCognitive impairments have been established as part of the non‐motor phenomenology of adult dystonia. In childhood dystonia, the extent of cognitive impairments is less clear. This systematic review aims to present an overview of the existing literature to elucidate the cognitive profile of primary and secondary childhood dystonia. MethodStudies focusing on cognition in childhood dystonia were searched in MEDLINE and PsychInfo up to October 2017. We included studies on idiopathic and genetic forms of dystonia as well as dystonia secondary to cerebral palsy and inborn errors of metabolism. ResultsThirty‐four studies ...
Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Systematic Review Source Type: research
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Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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