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The Role of the Corpus Callosum in Pediatric Dysphagia: Preliminary Findings from a Diffusion Tensor Imaging Study in Children with Unilateral Spastic Cerebral Palsy

AbstractThe purpose of this study is to determine the relationship between the structural integrity of the corpus callosum (CC) and clinical feeding/swallowing performance in children with unilateral spastic cerebral palsy (USCP). Twenty children with USCP, (11 males, 5.11 –17.6 yoa) were assessed via the Dysphagia Disorder Survey (DDS) and diffusion tensor imaging. Children were grouped into left hemisphere lesion (LHL;n = 13) and right hemisphere lesion (RHL;n = 7) groups. DTI variables analyzed for three CC regions (anterior, middle, posterior) were: fractional anisotropy (FA), radial diffusivity (RD), mean diffusivity (MD), and fibers count. Children with RHL presented with higher clinical dysphagia severity (p = 0.03). Six of seven children with RHL had lesions affecting periventricular/subcortical areas, and 8/13 children with LHL had lesions affecting the sensorimotor cortex. In the LHL group, as FA and fiber count of the anterior CC decreased and RD increased (all indicating reduced CC structural in tegrity), signs of dysphagia increased (r = −0.667,p = 0.013;r = −0.829,p ≤ 0.001;r = 0.594,p = 0.032, respectively). Reduced fiber count in the middle and posterior CC was also significantly associated with increased DDS scores (r = −0.762,p = 0.002;r = −0.739,p = 0.004, respectively). For the RHL group no ...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
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Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Review Source Type: research
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Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Commentary Source Type: research
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