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The Role of the Corpus Callosum in Pediatric Dysphagia: Preliminary Findings from a Diffusion Tensor Imaging Study in Children with Unilateral Spastic Cerebral Palsy

AbstractThe purpose of this study is to determine the relationship between the structural integrity of the corpus callosum (CC) and clinical feeding/swallowing performance in children with unilateral spastic cerebral palsy (USCP). Twenty children with USCP, (11 males, 5.11 –17.6 yoa) were assessed via the Dysphagia Disorder Survey (DDS) and diffusion tensor imaging. Children were grouped into left hemisphere lesion (LHL;n = 13) and right hemisphere lesion (RHL;n = 7) groups. DTI variables analyzed for three CC regions (anterior, middle, posterior) were: fractional anisotropy (FA), radial diffusivity (RD), mean diffusivity (MD), and fibers count. Children with RHL presented with higher clinical dysphagia severity (p = 0.03). Six of seven children with RHL had lesions affecting periventricular/subcortical areas, and 8/13 children with LHL had lesions affecting the sensorimotor cortex. In the LHL group, as FA and fiber count of the anterior CC decreased and RD increased (all indicating reduced CC structural in tegrity), signs of dysphagia increased (r = −0.667,p = 0.013;r = −0.829,p ≤ 0.001;r = 0.594,p = 0.032, respectively). Reduced fiber count in the middle and posterior CC was also significantly associated with increased DDS scores (r = −0.762,p = 0.002;r = −0.739,p = 0.004, respectively). For the RHL group no ...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Sammy Rolon is living in a makeshift clinic set up at a school. He has cerebral palsy and epilepsy, and is bed-ridden. He's waiting for surgery that was scheduled before Hurricane Maria smashed into Puerto Rico. Now he can't even get the oxygen he needs.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Electronic fetal monitoring (EFM) is the recommended method of intrapartum fetal surveillance for high-risk pregnancies. The cardiotocogram (CTG) trace forms a central piece of documentary evidence in medico-legal cases related to intrapartum hypoxia and birth asphyxia. Cardiotocography was introduced in 1960s as a screening tool with the view to reduce fetal hypoxic brain injury and cerebral palsy rates. However, its positive predictive value for intrapartum fetal hypoxia is as low as 30%, with false positive rate of around 60%.
Source: Obstetrics, Gynaecology and Reproductive Medicine - Category: OBGYN Authors: Tags: Case-based learning Source Type: research
Byrne and colleagues make an eloquent statement demonstrating the feasibility of “Implementation of Early Diagnosis and Intervention Guidelines for Cerebral Palsy in a High-Risk Infant Follow-Up Clinic1 ”. For the reader, it is natural to conclude that once identified, infants with a diagnosis of cerebral palsy (CP) are referred earlier for evidence-based therapeutic interve ntions in the community.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Correspondence Source Type: research
ConclusionsThe prevalence of undernutrition is high in cerebral palsy children. SGNA can be a reliable tool for assessing nutritional status in children with cerebral palsy and is a simple, comprehensive, noninvasive, and cost-effective tool for screening undernutrition in children of cerebral palsy.
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
AimTo investigate whether docosahexaenoic acid (DHA), choline, and uridine‐5‐monophosphate (UMP) supplementation improves neurodevelopmental outcome in infants with suspected cerebral palsy (CP) versus a comparison group of children. MethodInfants aged 1 to 18 months with suspected CP were recruited from UK child development centres. Participants received daily treatment or control supplementation for 2 years (double‐blind randomized control design). Stratification was by age, sex, predominant pattern of motor involvement (four limbs or other), and visual impairment (or not). The primary outcome was the cog...
Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Original Article Source Type: research
Conclusions and implications In high-funcitoning children with CP, there are positive ecological time trends in performance-related fitness, but not in VO2peak between 2004 and 2014. The substantial higher body mass and BMI is alarming and requires further investigation.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Abstract Neonatal ischemic brain injury causes permanent motor-deficit cerebral palsy. Hypoxic-ischemic encephalopathy (HIE) is a very serious condition that can result in death and disability. In 1997, we reported that irreversible neuronal cell damage is induced by the elevation of intracellular Ca ion concentration that has occurred in sequence after excess accumulation of the excitatory neurotransmitter glutamate during ischemia. We also reported that hypothermia was effective in treating ischemic brain damage in rats by suppressing energy loss and raising intracellular Ca ion concentration. Following the 2010...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Researchers have shed light on the mechanisms by which smoking before and during pregnancy could raise a child's risk of cerebral palsy.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Smoking / Quit Smoking Source Type: news
Publication date: Available online 6 October 2017 Source:PM&R Author(s): Seo Yeon Yoon, Yong Wook Kim, Ja Young Choi Bronchiectasis is a chronic pulmonary disease characterized by the permanent dilatation of the airways, with recurrent infections. As the disease progresses, extrapulmonary symptoms manifest. If the patient with bronchiectasis has an underlying central nervous system disease such as cerebral palsy (CP), extrapulmonary functions decline faster. The co-occurrence of these two diseases may make care more complex, and there have been no reports about pulmonary rehabilitation (PR) in this class of patients. ...
Source: PMandR - Category: Rehabilitation Source Type: research
ConclusionsThe development of CPUP‐Jordan registry for children with CP proved to be both feasible and informative. The registry baseline descriptive data were similar to those reported in previous research in Jordan supporting validity of the data. The implementation of CPUP‐Jordan at national level is expected to have a positive impact on children with CP, clinicians, policymakers, and researchers.
Source: Child: Care, Health and Development - Category: Child Development Authors: Tags: ORIGINAL ARTICLE Source Type: research
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