STING signaling in tumorigenesis and cancer therapy: A friend or foe?

Stimulator of interferon genes (STING) is a DNA sensor and an important cytoplasmic adaptor for other DNA sensors, such as Z-DNA binding protein 1 (DAI), DEAD-box helicase 41 (DDX41), and interferon- γ-inducible protein 16 (IFI16). The activation of STING signaling leads to the production of type I interferons and some other pro-inflammatory cytokines, and is critical for host defense against viral infection. Recent accumulating evidences suggest that STING is also involved in tumor development . However, the role of STING signaling in tumorigenesis is complicated, and a comprehensive review is still lacking.

Source: Cancer Letters - June 7, 2017 Category: Cancer & Oncology Authors: Liangmei He, Xiaomei Xiao, Xi Yang, Zixiang Zhang, Wu Longhuo, Zhiping Liu Source Type: research