A Distinctive Abnormality of Diffusion Tensor Imaging Parameters in the Fornix of Patients with Bipolar II Disorder

Diffusion tensor imaging (DTI) studies have revealed a changed integrity in the white matter of bipolar disorder. However, only a few investigations have examined bipolar II disorder (BP-II). A cross-sectional study was conducted to compare thirty-eight patients with BP-II (mean age = 38.26 years, F/M = 19/19) with thirty-eight age- and gender-matched healthy controls (mean age = 34.45 years, F/M = 18/20). Tract Based Spatial Statistics (TBSS) analysis of the fractional anisotropy (FA) was done with age, gender and education years as covariates, then a complementary atlas-based region-of-interest (ROI) analysis including the axial diffusivity (AD) and radial diffusivity (RD) was conducted to obtain further information.

Source: Psychiatry Research: Neuroimaging - June 7, 2017 Category: Psychiatry Authors: Akeo Kurumaji, Michio Itasaka, Akihito Uezato, Kazuo Takiguchi, Daisuke Jitoku, Mizue Hobo, Toru Nishikawa Source Type: research