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Macronutrient intake associated with weight gain in adolescent girls with anorexia nervosa

Abstract ObjectiveAdolescents and women with anorexia nervosa (AN) are known to severely restrict total calorie and fat intake. However, data are limited regarding specific macronutrient intake associated with weight gain in AN. ObjectiveTo prospectively investigate dietary macronutrient composition associated with weight gain in adolescent girls with AN. MethodA prospective naturalistic study of 90 girls 12–18 years old; 45 with AN and 45 healthy normal‐weight‐controls over a 6–12‐month period. Participants completed four‐day food diaries and underwent body composition assessment using dual energy x‐ray absorptiometry. Weight gain was defined as a ≥10% increase in BMI from baseline. ResultsBaseline clinical characteristics did not differ between girls with AN who did not gain weight (AN‐0) versus those who did (AN‐1) over the following 6–12 month period except for percentage of calories from proteins (p = 0.046). At 6–12 month follow up, AN‐1 consumed a lower percentage of total calories from protein (p = .001), and a higher percentage of total calories from fat (p = .02) compared to AN‐0. AN‐1 had a significant increase in the percentage of total calories obtained from and poly‐unsaturated‐fatty acids (PUFA) (p = 0.006) compared to AN‐0, between baseline and follow up. Within the AN group, BMI at follow‐up was associated positively with percentage of total calories...
Source: International Journal of Eating Disorders - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL ARTICLE Source Type: research

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CONCLUSIONS: The current study did not demonstrate a vitamin D deficiency in patients with AN and our data does not support vitamin D deficiency as a contributing factor to bone loss in AN. Instead, we observed a trend toward higher vitamin D levels in AN subjects compared to controls. Measurement of free vitamin D levels did not contribute to additional information. PMID: 28455680 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - Category: Eating Disorders and Weight Management Authors: Tags: Eat Weight Disord Source Type: research
We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT).
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Adolescent health brief Source Type: research
Conditions:   Anorexia Nervosa;   Osteoporosis;   Bone Remodelling Markers Intervention:   Device: DEXA Sponsor:   University Hospital, Lille Recruiting - verified September 2016
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ABSTRACT ObjectiveDSM‐5 revised the diagnostic criteria for anorexia nervosa (AN) by eliminating the amenorrhea requirement, liberalizing weight and psychological criteria, and adding the formal diagnosis of “atypical AN” for individuals with AN psychological symptoms without low weight. We sought to determine whether bone density (BMD) is impaired in women diagnosed with AN using the new, more liberal, DSM‐5 criteria. MethodCross‐sectional study of 168 women, 18 − 45y: (1) AN by DSM‐IV (DSM‐IV AN) (n = 37), (2) AN by DSM‐5 but not DSM‐IV criteria (DSM‐5 AN) (n&...
Source: International Journal of Eating Disorders - Category: Eating Disorders and Weight Management Authors: Tags: Original Article Source Type: research
DiscussionFat percentage and body mass index were positive predictors of the resumption of menses, however, body composition measured by dual energy X‐ray absorptiometry was not superior to body mass index in predicting menstrual recovery, which is of great clinical relevance as body mass index is easier and cheaper to obtain. Body composition measures only account for one of numerous factors involved in the resumption of menses. Regression models based on our data had a R2 value of 0.14, indicating that only 14% of the variation in menstrual recovery could be explained by the variables included. © 2016 Wiley Period...
Source: International Journal of Eating Disorders - Category: Eating Disorders and Weight Management Authors: Tags: Original Article Source Type: research
Abstract Summary We conducted the first comparison of dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) outcomes in adolescent girls with anorexia nervosa. We observed deficits in bone density by both tools. pQCT assessments were associated with many of the same clinical parameters as have been previously established for DXA. Introduction Adolescents with anorexia nervosa (AN) commonly exhibit bone loss, but effects on bone geometry are less clear. We compared measures obtained by DXA and pQCT in girls with AN....
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This study comprised 25 Swedish female AN patients (20.1 ± 2.3 years), who were treated as inpatients for 12 weeks with a high-energy diet. Serum 25-hydroxyvitamin D (25(OH)D), calcium, phosphate and parathyroid hormone (PTH) were measured. BMD and body composition were assessed by dual-energy X-ray absorptiometry at study start and after 12 weeks. Results Twenty-two patients completed the study. The mean weight gain was 9.9 kg and BMI (mean ± SD) increased from 15.5 ± 0.9 to 19.0 ± 0.9 kg/m2, P 
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Conclusions Immunomodulatory therapy shows positive outcomes in improving vomiting symptom in some gastroparetic patients who have coexisting positive autoimmune profiles. This preliminary data suggests the need for further investigations in immunotherapy targeted to patients with gastroparetic symptoms refractory to approved drug and device therapies.
Source: Results in Immunology - Category: Allergy & Immunology Source Type: research
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