Studies on binary mixtures of Pluronic P123 and twin tailed 1-Butyl-3-methyl-imidazolium Aerosol OT - Aggregation behavior and impact on Naproxen and Rifampicin partitioning

Publication date: September 2017 Source:Journal of Molecular Liquids, Volume 241 Author(s): Parvaiz Ahmad Bhat, Oyais Ahmad Chat, Aijaz Ahmad Dar Pluronic P123, 1-Butyl-3-methyl-imidazolium Aerosol OT ([Bmim][AOT]) and their binary mixtures at varied mole fractions have been investigated for micellization and rheological properties. The composition of the mixed micelles has been estimated on the basis of Clint, Gibbs adsorption, and Rubingh theories. The mixed micellar systems exhibited synergism for all the investigated mole fraction ranges with more pronounced synergism at intermediate mole fractions of [Bmim][AOT]. The gel behavior of P123 can be tuned by altering suitably mole fraction of surface active ionic liquids in order to tailor the system for desired applications. The investigated single/mixed micellar systems were explored for their solubilization capabilities toward two model hydrophobic drugs, Naproxen and Rifampicin. Regular solution parameter β was compared with deviation ratio R and surfactant-drug interaction parameter B to discuss mixing effect of surfactants on the partitioning of these drugs. Graphical abstract

Source: Journal of Molecular Liquids - June 7, 2017 Category: Molecular Biology Source Type: research