Arvoredol —An unusual chlorinated and biofilm inhibiting polyketide from a marine Penicillium sp. of the Brazilian coast

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Marina Scopel, Beatriz Mothes, Clea B. Lerner, Amélia T. Henriques, Alexandre J. Macedo, Wolf-Rainer Abraham Penicillium sp. F37 has been isolated from the marine sponge Axinella corrugata and shown to be closely related to Penicillium maximae. From the culture of Penicillium sp. F37 arvoredol, a novel chlorinated polyketide with 6,7-dihydro-4(5H)-benzofuranone moiety has been isolated and characterized by spectroscopic methods Arvoredol prevented biofilm formation of the human pathogen Staphylococcus epidermidis at a concentration of 125μgmL−1 by 40%. It was also active against colorectal carcinoma HCT116 cells with a MIC of 7.9μgmL−1. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research