Bacterial meningitis in Finland, 1995-2014: a population-based observational study

Conclusions Substantial decreases in bacterial meningitis were associated with infant conjugate vaccination against pneumococcal meningitis and secular trend in meningococcal meningitis in the absence of vaccination programme. Ongoing epidemiological surveillance is needed to identify trends, evaluate serotype distribution, assess vaccine impact and develop future vaccination strategies.
Source: BMJ Open - Category: General Medicine Authors: Tags: Open access, Epidemiology Research Source Type: research

Related Links:

This study reveals the presence of a multigene defensin family in I. holocyclus with wide antimicrobial activity.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, 13-15-months-old Holstein-Friesian steers were immunised with a subunit vaccine as a prime and a modified vaccinia Ankara vector as a boost, both expressing a chimeric multi-antigen (rMABbo – rMVA). This antigen includes the immunodominant B and T cell epitopes of three B. bovis proteins: merozoite surface antigen - 2c (MSA - 2c), rhoptry associated protein 1 (RAP - 1) and heat shock protein 20 (HSP20). Responses were compared with the Babesia bovis live attenuated vaccine used in Argentina (R1A). Eleven weeks after the first immunisation, all bovines were challenged by the inoculation of a virulent B....
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we aimed to elucidate the specific amino acids contributing to S2 epitopes. Site mutagenesis and peptide-based enzyme-linked immunosorbent assays (ELISAs) showed that 16R in S2 protein was a key amino acid mediating the antigenicity of S2 protein. S2-derived peptides with 16R, but not those with 16 K, could react with sera against different types of IBVs. Notably, a commercial ELISA kit for detection of antibodies against IBV did not react with sera against all types of IBVs. Taken together, these data demonstrated that S2-derived peptides with 16R could be used as novel marker-based antigens for deve...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this report, considering also the literature information, a case of G.sanguinis which is thought to cause meningitis was presented. Our case is a 39-year-old female patient with a lumboperitoneal shunt. The patient was admitted to the neurosurgery clinic with a headache and vision loss and was hospitalized in the service with a pre-diagnosis of pseudotumor cerebri. Neurological examination revealed no pathological findings. Eye examination revealed mild papillary edema, local retinal hemorrhage, and bilateral expansion in retinal vascularization. There was no pathologic findings in the brain magnetic resonance imaging. ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Fatemeh Sadat Tabatabaei Mirakabad, Maryam Sadat Khoramgah, Kamyar Keshavarz F., Maryam Tabarzad, Javad RanjbariAbstractPeptides are oligomers of amino acids, which have been used in a wide range of applications, particularly in medical and pharmaceutical sciences. Linear peptides have been extensively developed in various fields of medicine as therapeutics or targeting agents. The branched structure of peptide dendrimers with peptide (commonly, poly l‑Lysine) or non-peptide (commonly poly‑amidoamine) core, often exhibits valuable novel feat...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s): Jessica Hamzelou
Source: New Scientist - Category: Science Source Type: research
Meningitis can be a very scary infection — and vaccines can help prevent it. What is meningitis? The meninges are a membrane that covers and protects the brain and spinal cord. When that membrane gets inflamed, it’s called meningitis. One of the ways this inflammation can happen is from infection. Common symptoms of an infection of the meninges are fever, headache, and a stiff neck. There are many different germs that can infect the meninges. Viruses cause most cases, and while this can be serious, most people with viral meningitis get better without treatment. Some may not even realize they’ve had mening...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Infectious diseases Parenting Vaccines Source Type: blogs
Acute bacterial meningitis is a medical emergency, and delays in initiating effective antimicrobial therapy result in increased morbidity and mortality. Culture-based methods, thus far considered the "gold standard" for identifying bacterial microorganisms, require 24 to 48 h to provide a diagnosis. In addition, antimicrobial therapy is often started prior to clinical sample collection, thereby decreasing the probability of confirming the bacterial pathogen by culture-based methods. To enable a fast and accurate detection of the most important bacterial pathogens causing meningitis, namely, Streptococcus pneumoni...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Bacteriology Source Type: research
Authors: Kahraman H, Tünger A, Şenol Ş, Gazi H, Avcı M, Örmen B, Türker N, Atalay S, Köse Ş, Ulusoy S, Işıkgöz Taşbakan M, Sipahi OR, Yamazhan T, Gülay Z, Alp Çavuş S, Pullukçu H Abstract In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demog...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
The objective was to determine the optimal empirical antibiotics for bacterial meningitis in early infancy. METHODS: This was a cohort study of infants
Source: PEDIATRICS - Category: Pediatrics Authors: Tags: Infectious Disease, Neurology, Neurologic Disorders Article Source Type: research
More News: Epidemiology | General Medicine | Haemophilus Influenzae (Hib) | Influenza Vaccine | Laboratory Medicine | Listeria | Men | Meningitis | Meningitis Vaccine | Pneomococcal Vaccine | Study | Vaccines