Using Viruses to Boost Mesothelioma Immunotherapy

Immunotherapy through clinical trials is becoming a promising treatment option for some mesothelioma patients. Checkpoint inhibitor drugs, such as Keytruda, already have U.S. Food and Drug Administration (FDA) approval as first-line treatments for non-small cell lung cancer (NSCLC), edging immunotherapy drugs closer to becoming a viable second-line therapy for other thoracic cancers, including pleural mesothelioma. However, overall response to immune therapies remains relatively low. Researchers across the country are striving to enhance responsiveness to immunotherapy drugs. Leading that trend is viroimmunotherapy, or the process of combining cancer-killing (oncolytic) viruses with immunotherapy drugs. Dr. Manish Patel, an assistant professor in the division of hematology, oncology and transplantation at the University of Minnesota, has studied the potential of virus therapy for mesothelioma for several years. His research led to an ongoing clinical trial at the Mayo Clinic in Rochester, Minnesota, investigating the side effects and optimal dosage levels of using a genetically altered measles virus to kill mesothelioma tumor cells. Patel and Dr. Alexander Dash of Macalester College in St. Paul, Minnesota, recently published a paper in the journal Biomedicines that analyzes measles and other oncolytic viruses as potential viroimmunotherapy treatments for pleural mesothelioma and other thoracic cancers. As research continues, Patel believes the day of using viruses to in...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Biomedicines checkpoint blockade Checkpoint inhibitor drugs clinical trials for mesothelioma Dr. Alexander Dash Dr. Manish Patel FDA approval Keytruda immune response cancer immunotherapy response mesothelioma intratumoral injections k Source Type: news

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Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Felix Preisser, Elio Mazzone, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Michele Marchioni, Thomas Steuber, Fred Saad, Francesco Montorsi, Shahrokh F. Shariat, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. KarakiewiczAbstractCytoreductive radical prostatectomy (CRP) may offer a survival advantage, according to several retrospective analyses. However, few data are available regarding the morbidity of radical prostatectomy in the metastatic setting. We addressed intra- and postoperative complications of CRP relative to radical prosta...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Ilaria Cavarretta, Nicasio Mancini, Andrea Salonia
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Atiqullah Aziz, Matthias May, Oliver W. Hakenberg, Sabine D. Brookman-May
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONThe significance of BDR for pT2 or higher advanced GBC without biliary infiltration was equivocal because the patients received no survival benefit by undergoing BDR.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: European Journal of Surgical OncologyAuthor(s): Maria Anna Smolle, Michael Parry, Lee Jeys, Seggy Abudu, Robert GrimerAbstractObjectivesSynovial sarcoma, a distinct subtype of soft tissue sarcomas (STS), is typically found in young patients. Long history of symptoms and heterogeneous clinical presentation sometimes delays diagnosis. Children have been reported to have a better prognosis than adults in some series.The main emphasis of this study was to determine differences between children and adults and to investigate prognostic factors regarding cancer specific survi...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionTPE is an invasive treatment for rectal cancer with high 30-day mortality in elderly patients. Oncological outcomes are similar in elderly and younger patients. Therefore, TPE should not be withheld because of high age only, but careful patient selection is needed.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThe nomograms were able to more accurately predict 3- and 5-year OS and CSS of patients with GISTs than were existing models.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Sanjeevan Muruganandan, Maree Azzopardi, Deirdre B Fitzgerald, Ranjan Shrestha, Benjamin C H Kwan, David C L Lam, Christian C De Chaneet, Muhammad Redzwan S Rashid Ali, Elaine Yap, Claire L Tobin, Luke A Garske, Phan T Nguyen, Christopher Stanley, Natalia D Popowicz, Christopher Kosky, Rajesh Thomas, Catherine A Read, Charley A Budgeon, David Feller-Kopman, Nick A MaskellSummaryBackgroundIndwelling pleural catheters are an established management option for malignant pleural effusion and have advantages over talc slurry pleurode...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 20 July 2018Source: Journal of NeuroradiologyAuthor(s): Neesmah Authors:Badat, Cholet Clément, Hervé Geneviève, N Pyatigorskaya, S Trunet, D Dormont, Law-ye BrunoAbstractIntracranial epidermoid cysts (EC) are common congenital lesions accounting for approximately 1% of all intracranial tumors (1). Malignant transformation of EC is a rare but severe complication associated with poor prognosis (2). Our letter aims to depict a rare case of diffuse leptomeningeal carcinomatosis on skull base and trigeminal perineural spread of a squamous cell carcinoma (SCC) complicating an EC.
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
Publication date: Available online 20 July 2018Source: Diagnostic and Interventional ImagingAuthor(s): P. Kong, L. Chen, X. Shi, H. Pan, M. Yu, H. Ge, J. Zhu, G. Ma, L. Li, Q. Ding, W. Zhou, S. WangAbstractPurposeTo evaluate the mechanism for enhancing cell death induced by microwave ablation (MWA) combined with doxorubicin treatment in breast cancer cells.Materials and methodsDifferent temperatures of heat treatment were used to mimic the tumor affected by sublethal heat during MWA in vitro. Breast cancer cells were treated at 43 °C and 45 °C, with or without doxorubicin. Cell viability, apoptosis, and i...
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
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