Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes

Conclusions: These data suggest that Fxr and Shp inactivation may be beneficial to combat diet‐induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease. This article is protected by copyright. All rights reserved.

Source: Hepatology - June 6, 2017 Category: Internal Medicine Authors: Oludemilade Akinrotimi, Ryan Riessen, Philip VanDuyne, Jung Eun Park, Yoon Kwang Lee, Lee ‐Jun Wong, Ann M Zavacki, Kristina Schoonjans, Sayeepriyadarshini Anakk Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research