Real-world risk score for hepatocellular carcinoma risk prediction in CHBV: a validation outside of Asia

With great interest we have read the recent paper by Poh et al1 suggesting the use of a routine parameter-based risk score for the development of hepatocellular carcinoma (HCC) in Asian patients with chronic HBV infection (CHBV). With an estimated 240 million people being chronically infected by HBV worldwide, CHBV is a major global health burden, putting these people at risk for the development of liver cirrhosis and HCC.2–4 It remains challenging to identify those patients with CHBV carrying a high risk for HCC development applying an easy to use, readily available and cost effective test system. Therefore risk predicting scores ideally should be based on low cost parameters from routine clinical workup. The real-world risk score for HCC (RWS-HCC) perfectly meets these criteria. It is an 8-point score based on four routine parameters (gender, age, cirrhosis and serum α-fetoprotein)
Source: Gut - Category: Gastroenterology Authors: Tags: PostScript Source Type: research

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ConclusionsCirrhotic patients have higher odds of developing pulmonary complications, ascites, and anastomotic leak during the first postoperative month. Although, 30-day mortality was higher among cirrhotic patients after esophagectomy, liver disease does not seem to influence long-term prognosis.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 19 February 2020Source: Antiviral ResearchAuthor(s): Anthony T. Tan, Sophia SchreiberAbstractChronic hepatitis B virus (HBV) infection remains a major global concern due to its high prevalence and the increased probability of progressing toward cirrhosis and hepatocellular carcinoma (HCC). While currently available therapies are effective in controlling HBV replication, they rarely achieve functional cure. Similarly, effective treatment options for HBV-related HCC (HBV-HCC) are limited and primarily applicable only for early stages of the disease. With the general success of chimeric anti...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 18 February 2020Source: Antiviral ResearchAuthor(s): Shu Shi, Mingchen Liu, Jingyuan Xi, Hui Liu, Guiwen Guan, Congle Shen, Zhengyang Guo, Ting Zhang, Qiang Xu, Dilidaer kudereti, Xiangmei Chen, Jie Wang, Fengmin LuAbstractHepatitis B virus (HBV) infection is still a health care crisis in the world, and a considerable number of chronic hepatitis B patients die of end-stage liver diseases, including liver cirrhosis and hepatocellular carcinoma. A previous study has reported that sex-determining region Y box 4 (SOX4) promotes HBV replication by binding to the AACAAAG motif in the viral geno...
Source: Antiviral Therapy - Category: Virology Source Type: research
AbstractThe acute-phase protein pentraxin-3 (PTX3) is a component of the innate immune system. Inflammation and tissue injury increased PTX3 in the injured liver, and accordingly, circulating PTX3 was induced in patients with chronic liver diseases. In the present study, PTX3 protein was determined in systemic, hepatic, and portal vein plasma of patients with liver cirrhosis to assess a possible association between hepatic PTX3 release and extent of liver injury. However, PTX3 levels were not related to disease severity. Of note, portal PTX3 levels were higher than concentrations in the hepatic vein. PTX3 in the hepatic an...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
The objective is to guarantee similar waiting list mortality and similar posttransplant outcomes for each of these categories. SUMMARY: The French allocation system has been created with MELD as reference for prioritization, but it also takes into account distance between the donor and the recipient. Patients with hepatocellular carcinoma and patients with MELD exceptions are prioritized to have a similar access to transplantation. PMID: 32073486 [PubMed - as supplied by publisher]
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Authors: Canup BSB, Song H, Laroui H Abstract CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. The role of CD98 in liver disease has not thoroughly been examined and is limited reports in the literature. Among these reports, direct association for CD98 in nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) have been reported. Our lab has reported that targeting CD98 in high fat diet mice reduced steatosis and inflammation in NAFLD. Other reports associate CD98 in HCC du...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Several studies have demonstrated a decrease in liver-related events (LREs) in patients with cirrhosis who have achieved a sustained virological response (SVR) after direct-acting antiviral (DAA) therapy. However, good predictors to identify patients who remain at high risk of LREs have not been identified yet. Thus, the study by Pons et  al. describes the incidence of LREs in 572 patients with compensated advanced chronic liver disease who achieved SVR after DAA therapy. The most frequent LRE was hepatocellular carcinoma (HCC), which occurred in 25 patients (4.4%) at an incidence rate of 1.5/100 patient-year.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: From the Editor's Desk Source Type: research
ConclusionsFFMA as a measure of sarcopenia predicts OS and might represent a promising new biomarker for survival prognosis in patients undergoing RE for treatment of unresectable HCC.
Source: European Journal of Radiology - Category: Radiology Source Type: research
CONCLUSION: there is no association between higher BMI with HCC-related mortality in Asian race patients. PMID: 32041922 [PubMed - in process]
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
Globally, more than 170 million people are infected with hepatitis C virus, a major cause of cirrhosis and hepatocellular carcinoma. The Yinchenhao Decoction (YCHD) is a classic formula comprising three herbal...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
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