Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

Conclusions Differential DNA methylation at the PPAR promoter can be detected within the pool of cell-free DNA of human plasma. With further validation, plasma DNA methylation of PPAR could potentially be used to non-invasively stratify liver fibrosis severity in patients with NAFLD. Plasma DNA methylation signatures reflect the molecular pathology associated with fibrotic liver disease.
Source: Gut - Category: Gastroenterology Authors: Tags: Open access Hepatology Source Type: research