Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

Conclusions Pharmacological depletion of macrophages in a genetic mouse model of pancreatic cancer markedly reduced metastasis formation and is associated with impaired angiogenesis and reduced CD4+CD25+ T cell levels. Pharmacological targeting of infiltrating macrophages represents a promising novel tool for antimetastatic therapeutic approaches.

http://gut.bmj.com/cgi/content/short/66/7/1278?rss=1

Source: Gut - June 6, 2017 Category: Gastroenterology Authors: Griesmann, H., Drexel, C., Milosevic, N., Sipos, B., Rosendahl, J., Gress, T. M., Michl, P. Tags: Pancreas Source Type: research