Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

Conclusions
We showed that uc.158– is activated by the Wnt pathway in liver cancers and drives their growth. Thus, it may represent a promising target for the development of novel therapeutics.

Source: Gut - June 6, 2017 Category: Gastroenterology Authors: Carotenuto, P., Fassan, M., Pandolfo, R., Lampis, A., Vicentini, C., Cascione, L., Paulus-Hock, V., Boulter, L., Guest, R., Quagliata, L., Hahne, J. C., Ridgway, R., Jamieson, T., Athineos, D., Veronese, A., Visone, R., Murgia, C., Ferrari, G., Guzzardo, Tags: Open access GI cancer Source Type: research