Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

Conclusion These findings indicate that individuals with a defective intestinal barrier function and pre-existing inflammatory condition, such as IBD, might be negatively impacted by the use of TiO2 nanoparticles.
Source: Gut - Category: Gastroenterology Authors: Tags: Open access Inflammatory bowel disease Source Type: research

Related Links:

The authors of the published original version of the above article wanted to correct the below text in the Abstract section.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Condition:   Crohn Disease Interventions:   Diagnostic Test: PillCamTM Crohn's capsule;   Diagnostic Test: Magnetic resonance enterography;   Procedure: Ileo-colonoscopy Sponsors:   South Tyneside and Sunderland NHS Foundation Trust;   County Durham and Darlington NHS Foundation Trust;   Sheffield Teaching Hospitals NHS Foundation Trust;   Newcastle University;   Durham University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Crohn Disease Interventions:   Other: High-impact exercise intervention;   Other: Acute response to high-impact exercise Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Natural Killer (NK) cells were initially described as part of the innate immune system and characterized by their ability to lyse malignant and virus-infected cells. The cytolytic function of NK cells is tightly controlled by activating and inhibitory receptors expressed on the cell surface. Ligands that interact with a variety of NK-cell receptors include the human leukocyte antigen (HLA) molecules, and the regulation of NK-cell function by HLA class I molecules is well-established. Earlier studies also suggested a role of HLA class II molecules in regulating NK cell activity; yet, interactions between HLA class II molecu...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
New therapeutic approaches for chronic inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis are needed because current treatments are often suboptimal in terms of both efficacy and the risks of serious adverse events. Inhibitor of apoptosis proteins (IAPs) are E3 ubiquitin ligases that inhibit cell death pathways and are themselves inhibited by second mitochondria-derived activator of caspases (SMAC). SMAC mimetics (SMs), small-molecule antagonists of IAPs, are being evaluated as cancer therapies in clinical trials. IAPs are also crucial regulators of inflammatory pathways because t...
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Reviews Source Type: news
This article reviews the composition and function of the healthy human GI microbiome, including the relative abundances of different bacterial taxa and the specific metabolic pathways and classes of microbial metabolites contributing to human health and disease prevention.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
This study is a randomized clinical trial. Thirty patients with mild to moderate ulcerative colitis will be randomly allocated to receive a low FODMAP diet (n = 15) or to continue their usual diet as control (n = 15), for 4 weeks. The quantity of intestinal microbiota including Clostridium cluster IV,Faecalibacterium prausnitzii, Rosburia spp., Lactobacillus spp., Bifidobacteria spp.,Akkermansia muciniphila,Bacteroides fragilis, and Ruminococcus spp., and theFirmicutes toBacteroidetes ratio and calprotectin and lactoferrin levels will be explored in fecal samples from patients. In additio...
Source: Trials - Category: Research Source Type: clinical trials
Publication date: May 2020Source: Clinica Chimica Acta, Volume 504Author(s): Damian Jacenik, Jakub FichnaAbstractChemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Condition:   Crohn Disease Intervention:   Drug: Infliximab Sponsor:   Second Affiliated Hospital of Wenzhou Medical University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Environmental Health | Inflammatory Bowel Disease | Nanotechnology | Nutrition