Genomic Analysis of Childhood High Grade Glial Brain Tumors

Brain tumors are the most common malignant solid tumor in pediatrics and as a whole are the leading cause of cancer related mortality in children. Our study encompasses the subgroup of childhood brain tumors that carry the highest mortality rate, high grade gliomas (HGG), i.e., glioblastoma multiforme, anaplastic astrocytoma grade III, diffuse intrinsic pontine glioma. Adult HGG are more common and have been studied more extensively than histologically similar tumors in children. Studies have confirmed adult and pediatric HGG are biologically different.

Source: Cancer Genetics and Cytogenetics - June 6, 2017 Category: Genetics & Stem Cells Authors: Linda D. Cooley, Melissa Gener, Midhat Farooqi, Stephanie Fiedler, John Herriges, Jessica Nick, Elena Repnikova, Eugenio Taboada, Lei Zhang, Kevin Ginn Source Type: research