Celiac Disease Tests Do Not Reflect Ongoing Mucosal Damage Celiac Disease Tests Do Not Reflect Ongoing Mucosal Damage

Tests for serum transglutaminase (tTG) and endomysial antibodies (EMA) fail to detect persistent villous atrophy in many patients with celiac disease on gluten-free diets, according to a meta-analysis.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Gastroenterology News Source Type: news

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Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Marco Giannetto, Valentina Bianchi, Silvia Gentili, Simone Fortunati, Ilaria De Munari, Maria CareriAbstractA new compact diagnostic device exploiting the integration of screen printed electrode-based immunosensors and remote-controlled IoT-WiFi acquisition board has been realized and validated for diagnosis of Celiac Disease as case of study. The immunodevice is based on chemisorption of open tissue transglutaminase enzyme on the surface of gold nanoparticles-functionalized carbon screen printed electrodes. IgA and IgG anti-t...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
A monoclonal antibody could help reduce symptoms of coeliac disease in people with the condition who are accidentally exposed to gluten, show study findings presented at Digestive Disease Week.
Source: Clinical Pharmacist - Category: Drugs & Pharmacology Source Type: research
Myotonic dystrophy type 2 (DM2) is a dominantly inherited multisystem disorder caused by a CCTG repeat expansion in intron 1 of the CNBP gene on chromosome 3q21.3. DM2 is characterized by progressive proximal muscle weakness, myotonia, early-onset cataract, and multiorgan involvement including cardiac conduction abnormalities, gastrointestinal involvement and endocrine disturbances [1]. Autoimmune diseases are more prevalent (21%) and autoantibodies are more frequently detected (25%) in patients with DM2 compared to patients with myotonic dystrophy type 1 and the general population [2].
Source: Neuromuscular Disorders - Category: Neurology Authors: Tags: Case report Source Type: research
  In the first Wheat Belly book, I recounted the history of wheat from its wild-growing 14-chromosome einkorn ancestor, to the 28-chromosome emmer of Biblical times, to 42-chromosome spelt and other Triticum species, and finally to high-yield semi-dwarf strains created by agricultural scientists in the 1960s now comprises 99% of all wheat products sold. The quantity of additional changes introduced since are many, including selection of strains enriched in wheat germ agglutinin and phytates for their pest-resistant properties (while increasing human toxicity), gliadin and glutenin for desirable baking characteristics ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates gluten gluten-free grain-free grains health Inflammation wheat wheat belly Source Type: blogs
Conclusions The diagnostic yield for EGDs is increased in patients with more specific symptoms (i. e. dysphagia, heartburn, HP, celiac disease). Consequently, as an invasive procedure, EGD warrants a strict indication. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Klinische Padiatrie - Category: Pediatrics Authors: Tags: Original Article Source Type: research
Conclusions: Multiple symptoms and high serum anti-tTG antibody levels correlated with mucosal damage in children with CD. The role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of borderline CD is not yet established.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
Molecular Genetics&Genomic Medicine, EarlyView.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Conclusion: Overall, the KIDSCREEN-52 questionnaire revealed that CD had no substantial negative impacts on the children ’s QOL. However, some concerns from the children’s perspective were identified, such as issues regarding relationships with their peers. These issues will need to be addressed in order to improve QOL in children with CD.What is Known:•According to the Spanish version of the specific CDDUX, parents and children felt CD had no substantial negative impacts on their HRQOL.What is New:•According to the generic KIDSCREEN-52 questionnaire, QOL in Spanish coeliac children does not seem to b...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
ConclusionsOur review of quality improvement literature in gastroenterology revealed common themes of successful programs: Education was frequently used but often insufficient, the EMR may be underutilized in guiding decision making, and patient-reported outcomes were infrequently assessed. Further research may be needed to compare QI strategies directly.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
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