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Celiac Disease Tests Do Not Reflect Ongoing Mucosal Damage Celiac Disease Tests Do Not Reflect Ongoing Mucosal Damage

Tests for serum transglutaminase (tTG) and endomysial antibodies (EMA) fail to detect persistent villous atrophy in many patients with celiac disease on gluten-free diets, according to a meta-analysis.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Gastroenterology News Source Type: news

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This study investigated the initial presentation, the diagnostic process, follow-up evaluations, and adherence to a gluten-free diet in CeD patients in a real-life setting in Switzerland from a patient’s perspective. Methods: We performed a large patient survey among unselected CeD patients in Switzerland. Results: A total of 1689 patients were analyzed. The vast majority complained of both gastrointestinal and nonspecific symptoms (71.5%), whereas 1.8% reported an asymptomatic disease course. A total of 35.8% CeD patients were diagnosed by a nongastroenterologist. The diagnostic process differed between nongas...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Conclusions: The majority of patients we surveyed were satisfied with their CD care. We found that patients report higher satisfaction when they feel physicians spend time caring for their CD needs and when they receive annual CD-antibody testing. On the basis of our study, these factors are more important than disease severity, seeing a CD specialist, and quality of life in determining patient satisfaction with CD care.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
AbstractBackgroundThere has been a marked increase in the adoption of the gluten-free (GF) diet.AimsTo query individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS) on their beliefs toward the health effects of gluten, and safety of vaccines and GF food products.MethodsWe distributed a Web-based survey to individuals with CD and NCGS on a CD center e-mail list. We used univariate and multivariate analysis to compare responses of respondents with CD and NCGS.ResultsThe overall response rate was 27% (NCGSn = 217, CDn = 1291). Subjects with NCGS were more likely than those with CD to ...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Improved knowledge of comorbidities associated with juvenile idiopathic arthritis (JIA) could help identify complications, help direct long-term disease management, and determine prognosis. Associations of JIA with other autoimmune conditions, such as type 1 diabetes mellitus (T1D), autoimmune thyroiditis, and celiac disease, have been reported.1-4 Although previous studies reported an increased prevalence of autoimmune disorders in JIA,1,4 they were limited by relatively smaller cohort size and referral bias, precluding a definitive conclusion.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Editorials Source Type: research
Try our quiz, with questions taken from this year ’s learning and CPD articles, and check your knowledge of subjects ranging from sepsis and skin cancer to coeliac disease.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
ConclusionThough many bariatric patients may carry a presumptive diagnosis of celiac disease, a small percentage of these meet AGA diagnostic criteria. RYGB appears safe in this population with comparable weight loss in non-celiac counterparts. Increased attention to vitamin D levels may be warranted post-operatively.
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractLactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed. Term infants express sufficient lactase to digest about one liter of breast milk daily. Physiological lactose malabsorption in infancy confers beneficial prebiotic effects, including the establishment of Bifidobacterium-rich fecal microbiota. In many populations, lactase levels decline after weaning (lactase non-persistence; LNP). LNP affects about 70% of the world ’s population and is the physiological basis for primary lactose intolerance (L...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
The objective of this review was to summarize the findings linking gluten related conditions to pathophysiological substrates implicated in schizophrenia and mood disorders and review the evidences of potential benefits of glute-free diets in these populations. A literature search was conducted within PubMed and Scielo databases including references from inception until March 1st 2017. The strategy search was to use the key words “gluten”, “celiac disease”, “wheat”, “bipolar disorder”, “mood disorders”, “psychosis”, “schizophrenia”, “...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
The only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD). The restrictive nature of the GFD makes adherence a challenge. As an integral part of CeD management, multiple professional org...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
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