St. Jude-led study shows good news for childhood cancer survivors

According to a study led by St. Jude Children's Research Hospital, changes in how childhood cancer is treated have led to reduced risks of serious, long-term health effects due to cancer therapy. The Childhood Cancer Survivor Study (CCSS), funded by the National Cancer Institute, were unveiled June 2 at the annual meeting of the American Society of Clinical Oncology meeting in Chicago. “This is the first comprehensive study to demonstrate how changes in treatments over time have impacte d the…
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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There have been significant and continued improvements in the treatment for and survival from childhood cancer over the past few decades. Based on Australian and overseas statistics, the 5 year survival rates have improved to approximately 80% and the majority of these children will go on to become long term survivors (Baade et al., 2010; Gatta et al., 2009; Miller et al., 2016; Ries et al., 2008). Accompanying this increased survival, long-term physical and psychological consequences of cancer therapy are becoming more apparent.
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
ConclusionsOur study supports evidence of an increased risk for diabetes in survivors of childhood cancer. Future research is warranted for better identification of treatment-related risk factors for diabetes in this population.RésuméObjectifsGrâce à l'amélioration constante de la survie après un cancer chez l'enfant, les conséquences à long terme des traitements contre le cancer sur la santé retiennent de plus en plus l'attention. Le diabète apparaît comme une conséquence tardive potentielle de la thérapie contre le cancer. Toutefois,...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Chronic conditions as a result of cancer therapy can impact neurocognitive function of childhood cancer survivors.Journal of the National Cancer Institute
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Abstract Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Survivors of childhood cancer experience long-term increased SMN risk compared with the general population, with a greater than twofold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors after radiotherapy, with the highest risks for tumors occurring in or near the treatment field (eg, greater than fivefold increased risk for...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
ConclusionAlthough this population of women has above average knowledge scores, they still demonstrated a desire for more information on reproduction after cancer therapy. While PedsQL scores fell within a normal range, survivors report infertility would cause negative emotions.Implication for cancer survivorsThis information can be used refine educational programs within survivorship clinics to improve knowledge of post-treatment reproductive health.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Abstract Fortunately>80% of children diagnosed with cancer become long-term survivors; however, this population is at a significantly increased risk of morbidity and mortality as a result of their previous cancer therapy, and long-term follow-up (LTFU) is critical. Multiple barriers to receiving adequate LTFU care have been studied. We investigated whether lack of enrollment in a therapeutic clinical trial may be a barrier to receiving LTFU care. We conducted a review of 353 patient records at the Children's Hospital of Michigan enrolled in our Children's Oncology Group registry between January 1, 2005 and Dece...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: J Pediatr Hematol Oncol Source Type: research
Abstract Treatment-related side effects are a major clinical problem in cancer treatment. They lead to reduced compliance to therapy as well as increased morbidity and mortality. Well-known are the sequelae of chemotherapy on the heart, especially in childhood cancer survivors. Therefore, measures to mitigate the adverse events of cancer therapy may improve health and quality of life in cancer patients, both in short and long term. The renin angiotensin system (RAS) affects all hallmarks of cancer, and blockage of the RAS is associated with an improved outcome in several cancer types. There is also increasing evid...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
cute;rton I Abstract Mucositis is the most common oral complication of cancer therapy. Oral mucositis in childhood is more frequent and severe compared to adults, especially in children with leukemia. Lesions develop as the chemotherapeutic agents attack the rapidly dividing cells of the oral mucous membrane. Patients may experience trouble in eating, drinking, swallowing or even speaking due to the significant pain caused by the ulceration of the oral mucosa. Oral mucositis has a direct impact on the quality of life and may affect survival. The regular assessment of the oral mucosa is crucial during chemotherapy ...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
AbstractTake home figureModifiers of the association of childhood cancer therapies and excess CV risk observed in adult survivors, together with promising strategies for risk reduction and inherent barriers to achieving reduction in CV risk. CV, cardiovascular; GLS, global longitudinal strain; RT, radiation therapy.
Source: European Heart Journal - Category: Cardiology Source Type: research
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