St. Jude-led study shows good news for childhood cancer survivors

According to a study led by St. Jude Children's Research Hospital, changes in how childhood cancer is treated have led to reduced risks of serious, long-term health effects due to cancer therapy. The Childhood Cancer Survivor Study (CCSS), funded by the National Cancer Institute, were unveiled June 2 at the annual meeting of the American Society of Clinical Oncology meeting in Chicago. “This is the first comprehensive study to demonstrate how changes in treatments over time have impacte d the…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Abstract Neuro-oncology is a young and emerging discipline. An interdisciplinary mindset and concerted actions in specialized expert teams are required to meet the challenges, not only in clinical patient care but also in research activities. A close communication network between clinician scientists, medical scientists and data scientists is required to ensure that emerging data from basic, translational and clinical research can be used for improving the sometimes extremely limited and prognostically unsatisfactory treatment options. The continuously developing spectrum of tasks in neuro-oncology inclu...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
Purpose of review This systematic review evaluates the state of the art in terms of strategies used to detect and remove contaminated malignant cells from testicular biopsy prior to spermatogonia stem cells (SSCs) autotransplantation to restore fertility. Recent findings Several trials have been done in past two decades to determine the reliable methods of detecting and purging cancer cells prior to SSCs autotransplantation. Summary The success in treating childhood cancer has dramatically increased over the past few decades. This leads to increasing demand for a method of fertility preservation for patients with p...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: ANDROGENS: Edited by David Handelsman Source Type: research
Xuequn Xu†, J. N. Rashida Gnanaprakasam†, John Sherman† and Ruoning Wang* Center for Childhood Cancer and Blood Diseases, Hematology/Oncology &BMT, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, United States The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) through genetic engineering is one of the most promising new therapies for treating cancer patients. A robust CAR T cell-mediated anti-tumor response requires the coordination of nutrient and energy supplies with CAR T cell expansion and function. Howe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
The U.S. Food and Drug Administration approves a dozen cancer drugs every year, but the agency has greenlighted only six since 1978 specifically for childhood cancers. It’s not like adult cancers can always be repurposed for children at a lower dose. The causes of pediatric cancer are much different, and they generally have few mutations and occur when the normal development process is accentuated and inappropriately activated after birth. The National Cancer Institute estimated that more than…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
In conclusion, CAR-T treatment combined with intratumoral delivery of poly I:C resulted in synergistic antitumor activity. We thus provide a rationale to translate this immunotherapeutic strategy to solid tumors. Introduction Adoptive T cell immunotherapy has been demonstrated to be a new way to fight malignancies. In particular, T lymphocytes engineered to express chimeric antigen receptor (CAR) have shown great promise in treating hematological malignancies (1). CD19-targeted CAR-T cells have been approved by FDA to treat relapsed B cell acute lymphoblastic leukemia (B-ALL) and Diffuse Large B-cell lymphoma (DLBC...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeMore attention has been focused on the long-term side effects of treatment protocols since impressive advances in childhood cancer treatment have resulted in a growing population of patients. The purpose of this study was to investigate the disturbances of dento-facial development in children who were long-term survivors of childhood malignancies.MethodsFifty-three children (mean age, 10  years + 4 months) in long-term remission underwent oral/dental and radiographic examinations after completion of therapy. Crown and root malformations, gingival/periodontal status, enamel defects, di...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Enthusiasm for the use of antibody-drug conjugates (ADCs) in cancer therapy has risen over the past few years. The success of this therapeutic approach relies on the identification of cell surface antigens that are widely and selectively expressed on tumor cells. Studies have shown that native ALK protein is expressed on the surface of most neuroblastoma cells, providing an opportunity for development of immune-targeting strategies. Clinically relevant antibodies for this target have not yet been developed. Here, we describe the development of an ALK-ADC, CDX-0125-TEI, which selectively targets both wild-type and mutated A...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Purpose of review Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicate organs in young children, leading to multiple late effects. Deep understanding of the biology of embryonal cancers is crucial in reshaping the cancer treatment paradigm for children. Recent findings p53 plays a major physiological role in embryonic development, by controlling cell proliferation, differ...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: CANCER BIOLOGY: Edited by Pierre Hainaut Source Type: research
When I first visited the Children's Cancer Therapy Development Institute, I had a hard time finding the place. It's located along a fairly nondescript stretch of Beaverdam Road in Beaverton, adjacent to a smoke shop. The colorful door is the first clue that maybe this place is special. In fact, the institute occupies a former paint factory that Nike later turned into a creative space. Now there's million s of dollars worth of lab equipment inside, plus desks and mouse habitats fashioned by institute…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
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