Early-life exposure to caffeine affects the construction and activity of cortical networks in mice.

Early-life exposure to caffeine affects the construction and activity of cortical networks in mice. Exp Neurol. 2017 May 30;: Authors: Fazeli W, Zappettini S, Marguet SL, Grendel J, Esclapez M, Bernard C, Isbrandt D Abstract The consumption of psychoactive drugs during pregnancy can have deleterious effects on newborns. It remains unclear whether early-life exposure to caffeine, the most widely consumed psychoactive substance, alters brain development. We hypothesized that maternal caffeine ingestion during pregnancy and the early postnatal period in mice affects the construction and activity of cortical networks in offspring. To test this hypothesis, we focused on primary visual cortex (V1) as a model neocortical region. In a study design mimicking the daily consumption of approximately three cups of coffee during pregnancy in humans, caffeine was added to the drinking water of female mice and their offspring were compared to control offspring. Caffeine altered the construction of GABAergic neuronal networks in V1, as reflected by a reduced number of somatostatin-containing GABA neurons at postnatal days 6-7, with the remaining ones showing poorly developed dendritic arbors. These findings were accompanied by increased synaptic activity in vitro and elevated network activity in vivo in V1. Similarly, in vivo hippocampal network activity was altered from the neonatal period until adulthood. Finally, caffeine-exposed offspring showed increased seizure sus...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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Publication date: Available online 21 August 2019Source: Reproductive BioMedicine OnlineAuthor(s): Joyce S Xiao, Martin Healey, Alon Talmor, Beverley VollenhovenAbstractResearch questionIn patients with only one embryo on Day 3 post-IVF treatment, does transferring the embryo into the uterine environment achieve a higher pregnancy rate than growing the embryo on with a plan to transfer at Day 4–6?DesignThis was a retrospective cohort study conducted in patients with only one viable embryo on Day 3 post-IVF treatment. Data were extracted from a standardized IVF database and included 1384 women who fulfilled this study...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Conclusions: The surgeons performing LM in women pre-treated with UPA should be aware of the abnormal texture of enucleated myomas. Nevertheless, this does not negatively affect the other surgical and clinical outcomes of these patients. PMID: 31617772 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
This study examined the prevalence and risk factors of anaemia among ever-married women in Jordan using a secondary analysis of the Jordan Population and Family Health Survey. Methods: This is a secondary analysis of data from a nationally representative sample of ever-married women aged 15-49 years that were tested for haemoglobin levels in the 2012 JPFHS. Anaemia was categorized according to the WHO criteria. Univariate and multivariate logistic regression analyses were used to investigate risk factors associated with anaemia. Results: The prevalence of any anaemia was 37.3%; specifically, 20% had mild anaemia (h...
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
Publication date: November 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 11Author(s): Buyun Liu, Wei Bao
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: November 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 11Author(s): Yuan Yuan, Wenquan Niu
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Some recent things, a day late.AuditNational Pregnancy in Diabetes Audit 2018Perinatal Mortality Surveillance Report 20195th MBRRACE-UK reportPerinatal Mortality Review Tool- First annual reportStatisticsSex ratios at birth: Great Britain: 2013 to 2017NICE consultationsEpiscissors-60 for guided mediolateral episiotomyRoyal College of Physicians and Society for Acute MedicineEnsuring pregnant women get the right hospital treatment for urgent medical problems: acute care toolkitNewsBaby Friendly Initiative - University of Leicester Midwifery courses receive Certificate of Commitment for its Infant Feeding CafesAlcohol i...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
You're reading Top Tips To Streamline Your Pilates Experience, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Pilates is one of the most modern physical fitness systems to improve flexibility, build strength, and develop control and endurance in the whole body. Physical fitness and endurance varies from person to person. It is therefore quite logical to think that everyone needs a customized form of fitness system to suit their body and mind. Exercise is one of the most important activities that can not only regulate the...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness better health pilates Source Type: blogs
[New Times] The Minister of Gender and Family Promotion has urged communities to actively participate in tackling domestic violence and defilement, which has led to the rampant teenage pregnancies.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
[New Times] On October 14, a four-day campaign for National Integrated Maternal and Child Health was launched by the Ministry of Health in Karongi District but will be rolled out in every district.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
[New Times] As Rwanda joined the rest of the world to mark the International Day of Rural Women, on Tuesday, civil society organisations pointed out that teenage pregnancy and mistreatment of teenage mothers were still threats to the development of rural women.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
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