Caffeic Acid in dermatological formulations: in vitro release profile and skin absorption.

Caffeic Acid in dermatological formulations: in vitro release profile and skin absorption.
Comb Chem High Throughput Screen. 2017 Jun 01;:
Authors: Spagnol CM, Di Filippo LD, Isaac VLB, Corrêa MA, Salgado HRN
Abstract
Caffeic acid (CA) is a cinnamic acid derivative, found in many vegetable products, with powerful antioxidant activity, the ability to increase collagen production and capacity to prevent premature aging of the skin. The classic emulsions of CA are widely used by the consumer to provide a pleasant, refreshing sensorial experience; however, preparations developed in the form of dry film are presented as a technological alternative due to its facile and safe transportation. The aim of this study was to evaluate the release, permeation, and retention of CA in a film and emulsion through in vitro experiments. The release evaluation of CA from the emulsion and the film was performed using modified Franz diffusion cells, with an area of 1.77 cm², using Microette equipment (Hanson Research) with a cellulose membrane. The evaluation of the permeation of CA from the formulations was conducted using a similar technique of release, except that a biological membrane was used. High release of active compound and reduced permeation was observed, indicating that CA was able to be retained in the epidermis/dermis, where it should have the desired action. The concentration of caffeic acid in the skin was higher for the film formulation...

Source: Combinatorial Chemistry and High Throughput Screening - June 1, 2017 Category: Chemistry Authors: Spagnol CM, Di Filippo LD, Isaac VLB, Corrêa MA, Salgado HRN Tags: Comb Chem High Throughput Screen Source Type: research