RNA-based ovarian cancer research from 'a gene to systems biomedicine' perspective.
RNA-based ovarian cancer research from 'a gene to systems biomedicine' perspective.
Syst Biol Reprod Med. 2017 Jun 02;:1-20
Authors: Gov E, Kori M, Arga KY
Abstract
Ovarian cancer remains the leading cause of death from a gynecologic malignancy, and treatment of this disease is harder than any other type of female reproductive cancer. Improvements in the diagnosis and development of novel and effective treatment strategies for complex pathophysiologies, such as ovarian cancer, require a better understanding of disease emergence and mechanisms of progression through systems medicine approaches. RNA-level analyses generate new information that can help in understanding the mechanisms behind disease pathogenesis, to identify new biomarkers and therapeutic targets and in new drug discovery. Whole RNA sequencing and coding and non-coding RNA expression array datasets have shed light on the mechanisms underlying disease progression and have identified mRNAs, miRNAs, and lncRNAs involved in ovarian cancer progression. In addition, the results from these analyses indicate that various signalling pathways and biological processes are associated with ovarian cancer. Here, we present a comprehensive literature review on RNA-based ovarian cancer research and highlight the benefits of integrative approaches within the systems biomedicine concept for future ovarian cancer research. We invite the ovarian cancer and systems biomedicine research fiel...
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Gov E, Kori M, Arga KY Tags: Syst Biol Reprod Med Source Type: research
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