A simple high-dose gentamicin regimen showed no side effects among neonates.
CONCLUSIONS: The incidence of elevated S-gentamicin trough levels was increased among very premature neonates. However, no evidence of oto- or nephrotoxicity was observed. This simple regimen of gentamicin 5 mg/kg for the first three days should be considered for all neonates as it potentially minimises the risk of dosing errors and bacterial breakthrough infection.
FUNDING: none.
TRIAL REGISTRATION: Danish Data Protection Agency (2008-58-0035).
PMID: 28566120 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research