T2 Biosystems ’ T2MR detects Lyme disease-causing bacteria in blood

This study shows strong evidence that Lyme disease-causing bacteria exist transiently in blood,” co-author Dr. Thomas Fritsche said in prepared remarks. “T2MR is the only technology proven sensitive enough to directly detect these bacteria.” Traditionally, researchers use serology to diagnose Lyme disease by detecting antibodies that are triggered by the disease. There is no FDA-approved diagnostic based on direct measurement of Lyme disease-causing bacteria. Regulatory agencies recommend a 2-tiered approach to diagnose Lyme disease, but the technique detects 2 antibodies that require 1-2 weeks and 4-6 weeks to reach detectable levels, leaving a window where diagnosis of early Lyme disease is not possible. T2MR detected both confirmed cases of Lyme disease tested in the study, as well as 17 samples from patients thought to have Lyme disease. The company’s diagnostic system outperformed conventional PCR methods, which only detected 1 case of of Lyme disease-causing bacteria. Researchers also noted that T2’s system was much more analytically sensitive than conventional techniques. “T2MR is a method to detect Lyme spirochetes in whole blood that promises rapid and reliable sample-to-answer results and this study offers insight to how this diagnostic may improve clinical care for individuals with Lyme disease,” co-author Steven Callister added. The post T2 Biosystems’ T2MR detects Lyme disease-causing bacteria in blood appeared...
Source: Mass Device - Category: Medical Devices Authors: Tags: Diagnostics Wall Street Beat T2 Biosystems Inc. Source Type: news

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Semin Neurol 2019; 39: 440-447 DOI: 10.1055/s-0039-1692143Tick-borne infections—including tick-borne encephalitis viruses, represented in the United States by rare infections with Powassan and deer tick viruses, and more often Lyme disease—are of increasing importance to neurologists. Lyme neuroborreliosis (LNB) causes all or part of a triad including meningitis, radiculoneuritis, and cranial neuritis. Rarely, parenchymal brain and spinal cord involvement occur, with focal findings on examination and magnetic resonance imaging (MRI). LNB diagnosis requires plausible exposure, objective evidence of nervous syste...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
Authors: Brodziński S, Nasierowski T Abstract In the second part of the article case reports of three patients were presented. All patientswere treated for Borrelia infection and all of them developed psychotic disorders. History of each patient was different, as well as the probability of causal relationship between neuroborreliosis and psychosis. The first case concerns a female patient with no former psychiatric history, who developed psychotic episode secondary to neuroborreliosis. Psychotic disorders resolved after antibiotic treatment. In the second case, a male patient was previously twice hospitalized in p...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Brodziński S, Nasierowski T Abstract Borreliosis is a multisystem, bacterial, zoonotic infectious disease with diversified spectrumof symptoms, which may also include psychotic disorders. Clinical picture of the disease is often unspecific, which makes the diagnosis relatively difficult. Uncharacteristic process of borreliosis is a result of complex molecular strategies used by spirochetes to infect, disseminate and survive in host organism. Part I of the article is focused on the current knowledge about pathogenesis of Lyme Borreliosis (LB), especially neuroborreliosis. Additionally, epidemic situation i...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Four existing laboratory tests used to confirm a clinical diagnosis of Lyme disease recently received FDA market clearance for new testing indications that may help streamline the diagnostic process.
Source: JAMA - Category: General Medicine Source Type: research
Publication date: Available online 14 September 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Howard S. Ginsberg, Eric L. Rulison, Jasmine L. Miller, Genevieve Pang, Isis M. Arsnoe, Graham J. Hickling, Nicholas H. Ogden, Roger A. LeBrun, Jean I. TsaoAbstractIxodes scapularis is the primary vector of Lyme disease spirochetes in eastern and central North America, and local densities of this tick can affect human disease risk. We sampled larvae and nymphs from sites in Massachusetts and Wisconsin, USA, using flag/drag devices and by collecting ticks from hosts, and measured environmental variables to evaluate the enviro...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Three medical stories that we didn't cover, explained.Medscape
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Family Medicine/Primary Care Article Source Type: news
ConclusionsC. burnetii is rarely transmitted by ticks, but we proved that it is present in the environment, so it may be a danger to humans. The most common co-occurrence after tick bite concernsC. burnetii andB. burgdorferi.
Source: Infection - Category: Infectious Diseases Source Type: research
Dr Paul Auwaerter comments on the newly approved, modified two-tier approach for diagnosing Lyme disease.Medscape Infectious Diseases
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases Commentary Source Type: news
The periplasmic lipoprotein BB0365 of the Lyme disease agentBorrelia burgdorferi is expressed throughout mammalian infection and is essential for all phases of Lyme disease infection; its function, however, remains unknown. In the current study, our structural analysis of BB0365 revealed the same structural fold as that found in the NqrC and RnfG subunits of the NADH:quinone and ferredoxin:NAD+ sodium ‐translocating oxidoreductase complexes, which points to a potential role for BB0365 as a component of the sodium pump. Additionally, BB0365 coordinated Zn2+ by the His51, His55, His140 residues, and the Zn2+‐binding...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Article Source Type: research
Updated Date: Wed, 11 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
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