NIH researchers find potential genetic cause of Cushing syndrome

Finding may lead to therapies that prevent pituitary tumor recurrence.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news

Related Links:

Conclusions: Based on this study, males and females with ACTH-dependent Cushing’s syndrome present different clinical patterns. However, these differences do not justify different diagnostic strategies or treatment based on sex, considering the similar surgical outcome. Clinicians should be alert to diagnose accompanying osteoporosis (with fractures) in male patients with ACTH-dependent Cushing’s syndrome.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This article discusses the mechanisms involved in the pathogenesis of CS and the pros and the cons of the various antihypertensive agents that are presently available to treat these patients.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Yamamuro T, Inoue K, Nagai Y, Azuma D, Yamamoto A, Hara K, Kohara M, Iwata T, Nakatsuka S, Morii E, Yamamoto T Abstract Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical exami...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
We report the first case of transient ACTH-dependent CS, which appeared after combined ipilimumab and nivolumab therapy. Our patient presented typical clinical features of CS after three infusions of combined therapy, high serum and daily urinary free cortisol, and high serum ACTH levels. Pituitary MRI showed an enlargement of the pituitary gland suggesting ACTH secretion of pituitary origin, which was confirmed by inferior petrosal sinus sampling. The pituitary findings were preceded by thyroiditis. The evolution was characterized by spontaneous CS regression and subsequent appearance of severe corticotroph deficiency con...
Source: Melanoma Research - Category: Cancer & Oncology Tags: Short Communications Source Type: research
Authors: Bernini G, Tricò D Abstract Background Cushing's Syndrome (CS) is associated with a specific spectrum of dementia-like symptoms, including psychiatric disorders, such as major depression, anxiety and mania, and neurocognitive alterations, like impairment of memory and concentration. This pattern of clinical complications, which significantly impair the health-related quality of life of CS patients, is sometimes referred to as "steroid dementia syndrome" (SDS). The SDS is the result of anatomical and functional anomalies in brain areas involved in the processing of emotion and cognition, wh...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research
Authors: Tamada D, Kitamura T, Otsuki M, Oshino S, Saitoh Y, Shimomura I Abstract Cushing's syndrome (CS) is a clinical state caused by chronic excess of glucocorticoid, and results in hypertension, impaired glucose tolerance, and dyslipidemia. Recently, a mild state of pituitary CS without typical Cushingoid appearance (subclinical Cushing's disease; SCD) has been identified. However, the true prevalence of SCD and its effect on metabolic disorders remain obscure. The aim of this prospective study was to determine the prevalence of SCD according to the guideline proposed by the working group of the Japanese Minist...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
THE TREATMENT OF CUSHING'S DISEASE. Endocr Rev. 2015 Jun 11;:er20131048 Authors: Pivonello R, Leo M, Cozzolino A, Colao A Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome (CS), is a severe endocrine disease caused by a corticotroph pituitary tumor, associated with increased morbidity and mortality. The first-line treatment for CD is pituitary surgery, which is followed by disease remission in around 75%, and relapse in around 15%, of patients during the ten-year period after surgery. Patients with persistent or recurrent CD require additional treatments, including pituitary ra...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
CONCLUSION: In selected cases, unilateral, laparascopic adrenalectomy may serve as a life-saving procedure in a patient with ACTHdependent Cushing's syndrome. PMID: 25754284 [PubMed - in process]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
Editor: V. Dimov, M.D., Assistant Professor at University of ChicagoA painful swollen thigh in a diabetic patient: diabetic myonecrosis. The Lancet, 05/2014.Subperiosteal Bone Resorption due to primary hyperparathyroidism caused by parathyroid adenoma. NEJM, 05/2014.Eschar Formation from Testosterone Patch.Homozygous familial hypercholesterolaemia. Lancet, 04/2012.Insulin-Induced Lipohypertrophy. NEJM, 02/2012.Ectopic Cushing's Syndrome. NEJM, 12/2011.Porphyria Cutanea Tarda. NEJM, 09/2011.Auricular Cartilage Calcification and Adrenal Insufficiency. NEJM, 01/2011.Hemichorea –Hemiballism after Diabetic Ketoa...
Source: Clinical Cases and Images - Category: General Medicine Tags: Endocrinology Images Source Type: news
More News: American Health | Cushing's Syndrome | Genetics | National Institutes of Health (NIH) | Pituitary Tumor