Cardiac PET/CT in the Management of Cardiac Sarcoidosis: Association of FDG Uptake with Changes in Symptoms and Medications

Conclusion: While there is an association between worsening symptoms and increased FDG uptake in the myocardium, FDG uptake alone is not a strong predictor of symptom changes (AUC only 0.6). These results may be confounded by numerous factors including many known limitations of myocardial FDG inflammation imaging (e.g., incomplete FDG suppression, spatial resolution, motion) and the unknown impact of the effect of ongoing steroid therapy on baseline FDG trapping. These initial results suggest that patients with similar functional class had reduced FDG uptake if they were on steroids. Further work is needed to assess if steroids reduce FDG uptake independent of their therapeutic value. Research Support: None
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: The ' New Cardiomyopathies: Sarcoid, Amyloid, and Chemotherapy Source Type: research